Featured Research

from universities, journals, and other organizations

Surgery complications linked to chemotherapy delay, study finds

Date:
December 8, 2010
Source:
University of Michigan Health System
Summary:
Patients who have complications after colorectal cancer surgery are less likely to get chemotherapy, even when it is clearly recommended for their diagnosis, a new study finds.

Patients who have complications after colorectal cancer surgery are less likely to get chemotherapy, even when it is clearly recommended for their diagnosis, a new study from the University of Michigan Comprehensive Cancer Center finds.

Related Articles


In addition, patients with complications were more than twice as likely to have their chemotherapy delayed for more than 120 days after diagnosis or two months after surgery, which is considered the appropriate timeframe for receiving chemotherapy.

"Surgical complications are typically thought to be short-term problems, but our study suggests there is a clear link between downstream cancer care and complications that occur during surgery. This is critical because chemotherapy in this subset of colorectal cancer patients has clear lifesaving benefit," says lead study author Samantha Hendren, M.D., M.P.H., assistant professor of surgery at the U-M Medical School.

The study looked at data from 17,108 patients who had surgery for stage III colorectal cancer. Chemotherapy is recommended for all stage III colorectal cancer patients and has been shown to improve survival as much as 16 percent after five years. Patients were identified for the study from the Surveillance, Epidemiology and End Results-Medicare database, a large population-based registry.

Results of the study appear in the December issue of the journal Diseases of the Colon & Rectum.

Because chemotherapy stresses the body and slows healing, medical oncologists are generally reluctant to give chemotherapy to patients who are frail or unwell because of complications from surgery. Hendren also suggests that some patients may opt out of chemotherapy after experiencing surgical complications.

Complications include pneumonia, urinary tract infections, heart attack, wound infections, need for additional surgery or abscess drainage. Researchers believe that some of these complications can be prevented.

Nationally, variations exist among hospitals in use of chemotherapy for stage III colorectal cancer, and national quality guidelines focus on encouraging chemotherapy use. The researchers believe that surgical complications could be one factor that explains this disparity and urge hospitals to adopt quality measures to reduce complications.

"If we're going to try to improve compliance with chemotherapy guidelines, we need to be aware why patients are not getting it. Surgical complications could be part of that picture," says Hendren, noting that this will be the topic of her next study.

Colorectal cancer statistics: 142,570 Americans will be diagnosed with colorectal cancer this year and 51,370 will die from the disease, according to the American Cancer Society.

Additional authors: John D. Birkmeyer, M.D.; Huiying Yin, M.S., M.A.; Mousumi Banerjee, Ph.D.; Christopher Sonnenday, M.D., M.H.S.; and Arden M. Morris, M.D., M.S., all from the University of Michigan Medical School

Funding: The authors are supported by grants from the American Cancer Society and the National Cancer Institute.


Story Source:

The above story is based on materials provided by University of Michigan Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hendren, Samantha; Birkmeyer, John D.; Yin, Huiying; Banerjee, Mousumi; Sonnenday, Christopher; Morris, Arden M. Surgical Complications Are Associated With Omission of Chemotherapy for Stage III Colorectal Cancer. Diseases of the Colon & Rectum, 2010; 53 (12): 1587-1593 DOI: 10.1007/DCR.0b013e3181f2f202

Cite This Page:

University of Michigan Health System. "Surgery complications linked to chemotherapy delay, study finds." ScienceDaily. ScienceDaily, 8 December 2010. <www.sciencedaily.com/releases/2010/12/101208125628.htm>.
University of Michigan Health System. (2010, December 8). Surgery complications linked to chemotherapy delay, study finds. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2010/12/101208125628.htm
University of Michigan Health System. "Surgery complications linked to chemotherapy delay, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/12/101208125628.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins