Featured Research

from universities, journals, and other organizations

Protein targeted to stop melanoma tumor growth

Date:
December 27, 2010
Source:
Penn State
Summary:
Halting the growth of melanoma tumors by targeting the MIC-1 protein that promotes blood vessel development in tumors may lead to better treatment of this invasive and deadly cancer, according to new research.

Halting the growth of melanoma tumors by targeting the MIC-1 protein that promotes blood vessel development in tumors may lead to better treatment of this invasive and deadly cancer, according to Penn State College of Medicine researchers in The Foreman Foundation Research Laboratory.

"Preventing vessels from developing in tumors is one way to stop them from growing," said lead author Gavin Robertson, Ph.D., professor of pharmacology, pathology, dermatology and surgery. "However, the identity of the proteins secreted by tumors cells enabling the angiogenesis process to occur remains to be determined." Angiogenesis is the growth of new blood vessels from existing ones surrounding the growing tumor mass.

Tumors start as clusters of cells that transport nutrition and waste through cell walls as well as into and out of gaps between cells. This process is inefficient and provides poor nutrition to the cells in the interior of a growing tumor. As a result, the tumor mass cannot grow.

Tumor cells overcome this obstacle by secreting proteins that interact with blood vessels surrounding the tumor, causing formation of new vessels from these existing ones. The new vessels grow into the tumor to provide nutrition and remove waste. Angiogenesis leads to the formation of a fully functioning vascular structure that supplies the needed nutrition and removes cell waste, allowing tumors to grow.

By targeting the proteins that lead to angiogenesis, tumor growth can be halted. In the past, the protein VEGF was identified as a major factor in this process. However, targeting VEGF alone does not prevent tumor development in melanoma patients. The researchers looked for other proteins involved in angiogenesis and ultimately discovered MIC-1 as a regulator of this process.

The researchers reported in the American Journal of Pathology that MIC-1 is present in levels five to six times higher in 67 percent of melanoma patients compared to people without cancer.

"This suggests that the MIC-1 protein produced and secreted by these tumors might be performing an important role in the development of melanoma by controlling a key process outside of the tumor," Robertson said.

MIC-1 stands for macrophage inhibitory cytokine-1, a member of a group of proteins that regulate cellular proliferation, migration, adhesion and immune surveillance. It was originally discovered to be associated with regulating inflammation.

By targeting MIC-1, protein levels dropped 300 to 400 percent in animal and human tissue samples, preventing blood vessel formation and decreasing tumor development by about 300 percent.

"Therapies removing MIC-1 from the blood of patients could be used to prevent tumor vessel development," says Robertson "and as a result, the tumors would not be able to get bigger because of a lack of needed nutrition and removal of toxic cell waste products. Thus, a drug performing the job of MIC-1 removal would be an important part of a therapeutic arsenal of agents to more effectively treat melanoma."

Working with Robertson are graduate students Sung Jin Huh and Chin-Ying Chung, Department of Pharmacology; and Arati Sharma, Ph.D., assistant professor, Department of Pharmacology.

The National Institutes of Health, American Cancer Society and The Foreman Foundation for Melanoma Research funded this research.


Story Source:

The above story is based on materials provided by Penn State. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. J. Huh, C.-Y. Chung, A. Sharma, G. P. Robertson. Macrophage Inhibitory Cytokine-1 Regulates Melanoma Vascular Development. American Journal Of Pathology, 2010; 176 (6): 2948 DOI: 10.2353/ajpath.2010.090963

Cite This Page:

Penn State. "Protein targeted to stop melanoma tumor growth." ScienceDaily. ScienceDaily, 27 December 2010. <www.sciencedaily.com/releases/2010/12/101209101501.htm>.
Penn State. (2010, December 27). Protein targeted to stop melanoma tumor growth. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2010/12/101209101501.htm
Penn State. "Protein targeted to stop melanoma tumor growth." ScienceDaily. www.sciencedaily.com/releases/2010/12/101209101501.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins