Featured Research

from universities, journals, and other organizations

Cholera strain evolves new mechanism for causing disease

Date:
December 10, 2010
Source:
American Society for Microbiology
Summary:
New clinical strains of cholera appear to have evolved a distinctly different mechanism to cause the same disease, according to new research.

New clinical strains of cholera appear to have evolved a distinctly different mechanism to cause the same disease, according to research published in the current issue of the online journal mBio.

Vibrio cholerae is the causative agent for the diarrheal disease cholera. While there are more than 200 different serogroups only the O1 and the O139 strains have been known to cause epidemic and pandemic outbreaks of disease, using a toxin-coregulated pilus (TCP) and cholera toxin (CT), which other strains lack.

"While non-O1, non-O139 strains have caused sporadic disease globally, the virulence mechanisms are not fully understood, since most of these strains lack TCP and CT," say the researchers from Harvard Medical School and the International Center for Diarrhoeal Research in Dhaka, Bangladesh.

The researchers studied a newly identified non-O1, non-O139 strain of the bacteria called AM-19226. Using comparative genomics, they investigated how this new strain causes diarrhea.

Many pathogenic bacteria require something called a type III secretion system (T3SS) in order to cause disease. In previous studies, the researchers discovered a T3SS and identified a protein (vopF) that they believe could be involved in causing disease.

In the current study they identified an additional protein (vopE) and using mouse models show that AM-19226 requires T3SS to cause diarrhea and that both vopE and vopF contribute to the disease.

"With the discovery of the T3SS in V. cholerae and its role in the virulence of non-O1 and non-O139 strains, it is astonishing to observe how this bacterium has evolved two independent pathogenic mechanisms to cause similar disease," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. V. C. Tam, M. Suzuki, M. Coughlin, D. Saslowsky, K. Biswas, W. I. Lencer, S. M. Faruque, J. J. Mekalanos. Functional Analysis of VopF Activity Required for Colonization in Vibrio cholerae. mBio, 2010; 1 (5): e00289-10 DOI: 10.1128/mBio.00289-10

Cite This Page:

American Society for Microbiology. "Cholera strain evolves new mechanism for causing disease." ScienceDaily. ScienceDaily, 10 December 2010. <www.sciencedaily.com/releases/2010/12/101209121431.htm>.
American Society for Microbiology. (2010, December 10). Cholera strain evolves new mechanism for causing disease. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2010/12/101209121431.htm
American Society for Microbiology. "Cholera strain evolves new mechanism for causing disease." ScienceDaily. www.sciencedaily.com/releases/2010/12/101209121431.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins