Featured Research

from universities, journals, and other organizations

Obesity research targets brain's use of fatty acids

Date:
January 5, 2011
Source:
University of Colorado Denver
Summary:
Researchers have created a promising new mouse model to study how lipid sensing and metabolism in the brain relate to the regulation of energy balance and body weight.

Researchers at the University of Colorado School of Medicine have created a promising new mouse model to study how lipid sensing and metabolism in the brain relate to the regulation of energy balance and body weight.

The research team, led by Hong Wang, PhD, created mice with a deficiency of lipoprotein lipase (LPL) in neurons, and observed two important reactions. First, the mouse models ate more; and second, they became sedentary. Because LPL is important to the delivery of fatty acids to the brain, these responses spotlight the importance of fatty acid delivery to the brain in the regulation of body weight.

"This work may have important impact in understanding the causes of obesity and providing new treatments for this epidemic of our time," said Robert H. Eckel, MD, corresponding and senior author of "Deficiency of Lipoprotein Lipase in Neurons Modifies the Regulation of Energy Balance and Leads to Obesity" which was published in Cell Metabolism.

The genetically-modified mouse (NEXLPL) has a defect in the breakdown of dietary lipoprotein triglycerides into fatty acids in the brain. These mice became obese on a standard chow diet between three and six months. At that point, the mice ate less and were less active.

The research also looked at which areas of the brain have the greatest impact on regulating body weight and learned that the hypothalamus may be the key area to observe as NEXLPL mice have increases in hypothalamic AgRP/NPY gene expression before obesity. AgRP/NPY cause increases in food intake and decreases in energy expenditure. Researchers also noted that the NEXLPL mice demonstrate deficiencies in n-3 fatty acids in the hypothalamus. Overall, this research indicates that the lipoproteins are sensed in the brain by an LPL-dependent pathway and provide lipid signals for the central regulation of body weight and energy balance.

The research team included scientists in the Division of Endocrinology, Metabolism and Diabetes in the Department of Medicine at the CU School of Medicine; the Department of Pharmacology at the University of California Irvine; the Department of Neurogenetics at the Max-Planck-Institute of Experimental Medicine in Germany; the Italian Institute of Technology in Genoa, Italy and the Department of Medicine at Columbia University in New York.


Story Source:

The above story is based on materials provided by University of Colorado Denver. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hong Wang, Giuseppe Astarita, Matthew D. Taussig, Kalyani G. Bharadwaj, Nicholas V. DiPatrizio, Klaus-Armin Nave, Daniele Piomelli, Ira J. Goldberg, Robert H. Eckel. Deficiency of Lipoprotein Lipase in Neurons Modifies the Regulation of Energy Balance and Leads to Obesity. Cell Metabolism, 2011; 13 (1): 105-113 DOI: 10.1016/j.cmet.2010.12.006

Cite This Page:

University of Colorado Denver. "Obesity research targets brain's use of fatty acids." ScienceDaily. ScienceDaily, 5 January 2011. <www.sciencedaily.com/releases/2011/01/110104151148.htm>.
University of Colorado Denver. (2011, January 5). Obesity research targets brain's use of fatty acids. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2011/01/110104151148.htm
University of Colorado Denver. "Obesity research targets brain's use of fatty acids." ScienceDaily. www.sciencedaily.com/releases/2011/01/110104151148.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins