Featured Research

from universities, journals, and other organizations

Quality of life measures in breast cancer clinical trials

Date:
January 7, 2011
Source:
Journal of the National Cancer Institute
Summary:
Quality of life measures tend to be most useful for clinical decision-making in trials in which quality of life is the primary outcome, according to a recent study.

Quality of life measures tend to be most useful for clinical decision-making in trials in which quality of life is the primary outcome, according to a recent study published online January 7 in The Journal of the National Cancer Institute.

Related Articles


There has been increasing interest in the value of patient-reported symptom assessment in trials and their potential usage as primary or secondary endpoints in new trials. Both the World Health Organization and the U.S. Food and Drug Administration have endorsed quality of life, but they are not always incorporated into trials because of the additional resources needed for data collection. But quality of life measures remain important for women who have completed therapy and many have symptoms such as fatigue, cognitive complaints, sleep and sexual problems, and neuropathy. At the other end of the spectrum, for advanced breast cancer patients on palliative treatments with toxicities, it would be important to determine if any observed survival benefit is outweighed by that burden.

To determine how quality of life measures are used in clinical trials, Julie Lemieux, M.D., of the Université Laval in Québec, Canada, and colleagues, conducted a literature search for articles that reported a randomized clinical trial of breast cancer treatment in which quality of life was an endpoint.

Their review included 190 randomized clinical trials -- 103 on biomedical interventions, and 87 on non-biomedical interventions, such as psychosocial interventions like the effect of group therapy on patient outcomes.

The authors found that QOL measures were most useful for clinical decisions in trials using non-biomedical interventions.

They also found that quality of life measurements should be included as a secondary endpoint in adjuvant therapy trials only when the medical outcome is expected to be about the same, or if the study focuses on a vulnerable population such as the elderly; or tests a new intervention for which quality of life information needs to be obtained. They should also be included in metastatic breast cancer trials when a minimal survival difference is expected; or treatments have substantial differences in toxicity.

They also write that when QOL is not the primary endpoint of a trial, "QOL results should ideally appear in a companion article published at the same time as the traditional medical outcomes article so that a full view of the risks and benefits of the intervention can be presented at the same time to clinicians."

In an accompanying editorial, Patricia A. Ganz, M.D., of UCLA, writes, "The large increase in the number of published studies identified in this high-quality systematic review reflects the increased acceptance of the patient's voice in assessing the outcome of trials as well as the participation of expert QOL investigators in the design, conduct, and analysis of clinical trials."

Ganz also writes, "Inclusion of well-validated measures of relevant symptoms should be a high priority for assessing the burden of breast cancer treatments, whether in survivors of breast cancer or in women with advanced disease receiving palliative care."


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Julie Lemieux, Pamela J. Goodwin, Louise J. Bordeleau, Sophie Lauzier, and Valérie Théberge. Quality-of-Life Measurement in Randomized Clinical Trials in Breast Cancer: An Updated Systematic Review (2001–2009). Journal of the National Cancer Institute, Jan 7, 2010 DOI: 10.1093/jnci/djq508

Cite This Page:

Journal of the National Cancer Institute. "Quality of life measures in breast cancer clinical trials." ScienceDaily. ScienceDaily, 7 January 2011. <www.sciencedaily.com/releases/2011/01/110107195908.htm>.
Journal of the National Cancer Institute. (2011, January 7). Quality of life measures in breast cancer clinical trials. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2011/01/110107195908.htm
Journal of the National Cancer Institute. "Quality of life measures in breast cancer clinical trials." ScienceDaily. www.sciencedaily.com/releases/2011/01/110107195908.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) — An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins