Featured Research

from universities, journals, and other organizations

Sex, race, and geography influence health outcomes following primary HIV infection

Date:
January 18, 2011
Source:
Infectious Diseases Society of America
Summary:
Women, nonwhites, and people in the southern United States who were newly infected with HIV and followed for an average of four years experienced greater HIV/AIDS-related morbidity compared to men and people of other races living in other regions of the country. The findings underscore the urgent need to improve the health of these populations in order to reduce HIV-related morbidity and mortality in the US.

Women, nonwhites, and people in the southern United States who were newly infected with HIV and followed for an average of four years experienced greater HIV/AIDS-related morbidity compared to men and people of other races living in other regions of the country. The findings, published in the February 15 issue of The Journal of Infectious Diseases, underscore the urgent need to improve the health of these populations in order to reduce HIV-related morbidity and mortality in the U.S.

The researchers did not expect women to show the worst health outcomes because their viral loads were lower and CD4+ T cell counts were higher than men's following diagnosis, reported study author Amie L. Meditz, MD, of the University of Colorado- Denver. (The study was part of the Acute Infection and Early Disease Research Program, a multicenter study network funded by the National Institute of Allergy and Infectious Diseases.) However, during the course of the study (1997-2007), the frequency of HIV-related illnesses in women was more than double that of men, with nonwhite women having the most negative outcomes. After eight years of infection, HIV-related events affected 64 percent of nonwhite women, and AIDS-defining events occurred in 22 percent of nonwhite women. In comparison, HIV-related and AIDS-defining events occurred in 21 percent and 6 percent of individuals in other combined race and sex groups, respectively.

The data representing subjects from the southern U.S. show that race and region play a major role in health outcomes of both women and men infected with HIV. Eight years following their diagnosis, 78 percent of nonwhites and 37 percent of whites in the southern U.S. had experienced one or more HIV/AIDS-related event, compared to 17 percent of nonwhites and 24 percent of whites in other geographic locations.

According to the investigators, race-sex differences in response to antiretroviral therapy were nonexistent. The researchers observed that nonwhite women and men and individuals from the South were not as likely as white men and individuals from other regions of the U.S. to initiate antiretroviral therapy. Nevertheless, use of antiretroviral therapy only explained part of the differences in outcomes. The authors hypothesized that the disparities could be attributed to the influence of socioeconomic factors, including "access to health care, health behaviors, lifestyle, and environmental exposures." Delayed therapy may be one factor affecting increased morbidity in HIV-infected individuals living in the South; however, socioeconomic factors probably also play a role.

In an accompanying editorial, Carlos del Rio, MD, and Wendy S. Armstrong, MD, of Emory University's Center for AIDS Research in Atlanta, commented on the challenges presented in the study. The likelihood of HIV-infected individuals seeking care depends on factors not related purely to biology, and it is critical to consider socioeconomic factors when developing care strategies for these individuals. They noted that "socioeconomic factors play a much more important role in determining HIV disease outcomes, both at an individual as well as at a population level, and although theoretically modifiable, they represent complex challenges that are beyond the traditional influence of public health."

Dr. Meditz concluded that "understanding the causes of poor health outcomes among HIV-infected women, nonwhites and people from the South is a critical first step. In addition, development of strategies or interventions to improve health outcomes in these populations is essential."

Notes

  1. The researchers evaluated data from more than 2,000 primarily North American patients who were identified within a year of acquiring HIV infection and then were followed for an average of four years.
  2. The majority of men (77 percent) in the study were white, while the majority of women (55 percent) were nonwhite. Almost half (45 percent) of nonwhite women were from the southern U.S., and 79 percent of women from the South were nonwhite.
  3. Antiretroviral therapy was less likely to be started at any time point by nonwhite women and men compared to white men and by individuals from the southern U.S. compared to others.
  4. Women were 2.17-fold more likely to experience more than one HIV/AIDS-related event than men. Further, nonwhite women were most likely to experience an HIV/AIDS-related event compared to all others.
  5. In the study, 78 percent of nonwhites and 37 percent of whites from the southern U.S. experienced more than one HIV/AIDS-related event eight years after diagnosis, compared to 24 percent of whites and 17 percent of nonwhites from other regions.

Story Source:

The above story is based on materials provided by Infectious Diseases Society of America. Note: Materials may be edited for content and length.


Journal References:

  1. Amie L. Meditz, Samantha Mawhinney, Amanda Allshouse, William Feser, Martin Markowitz, Susan Little, Richard Hecht, Eric S. Daar, Ann C. Collier, Joseph Margolick, J. Michael Kilby, Jean-Pierre Routy, Brian Conway, John Kaldor, Jay Levy, Robert Schooley, David A. Cooper, Marcus Altfeld, Douglas Richman, Elizabeth Connick. Sex, Race, and Geographic Region Influence Clinical Outcomes Following Primary HIV-1 Infection. Journal of Infectious Diseases, 2011; DOI: 10.1093/infdis/jiq085
  2. Wendy S. Armstrong, Carlos del Rio. Gender, Race, and Geography: Do They Matter in Primary Human Immunodeficiency Virus Infection? Journal of Infectious Diseases, 2011; DOI: 10.1093/infdis/jiq088

Cite This Page:

Infectious Diseases Society of America. "Sex, race, and geography influence health outcomes following primary HIV infection." ScienceDaily. ScienceDaily, 18 January 2011. <www.sciencedaily.com/releases/2011/01/110118091929.htm>.
Infectious Diseases Society of America. (2011, January 18). Sex, race, and geography influence health outcomes following primary HIV infection. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2011/01/110118091929.htm
Infectious Diseases Society of America. "Sex, race, and geography influence health outcomes following primary HIV infection." ScienceDaily. www.sciencedaily.com/releases/2011/01/110118091929.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
WHO: Ebola Cases to Triple in Weeks Without Drastic Action

WHO: Ebola Cases to Triple in Weeks Without Drastic Action

AFP (Sep. 23, 2014) The number of Ebola infections will triple to 20,000 by November, soaring by thousands every week if efforts to stop the outbreak are not stepped up radically, the WHO warned in a study on Tuesday. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
5 Ways Men Can Prevent Most Heart Attacks

5 Ways Men Can Prevent Most Heart Attacks

Newsy (Sep. 23, 2014) No surprise here: A recent study says men can reduce their risk of heart attack by maintaining a healthy lifestyle, which includes daily exercise. Video provided by Newsy
Powered by NewsLook.com
Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins