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Selective estrogen signaling key to postmenopausal risk of obesity

Date:
January 18, 2011
Source:
Journal of Clinical Investigation
Summary:
Although the hormone estradiol-17-beta is a key reproductive hormone, it also contributes to the regulation of energy balance and body weight. As a result, estrogen deficiency following menopause is associated with an increased probability of obesity. New research has generated data that suggest it might be possible to develop drugs that selectively reduce the risks of obesity and metabolic disturbances in postmenopausal women.

The hormone estradiol-17-beta is a key reproductive hormone. However, it also contributes to the regulation of energy balance and body weight. As a result, estrogen deficiency following menopause is associated with an increased probability of obesity and increased risk for developing type 2 diabetes.

A team of researchers, led by Jon Levine, at Northwestern University, Evanston, has now generated new insight into the mechanisms by which ER-alpha signaling maintains normal energy balance. Specifically, the team found that nonclassical ER-alpha signaling is key to the effects of estradiol-17-beta on energy balance.

These data lead them to suggest that it might be possible to develop drugs that selectively activate nonclassical ER-alpha signaling to reduce the risks of obesity and metabolic disturbances in postmenopausal women.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Cheryl J. Park, Zhen Zhao, Christine Glidewell-Kenney, Milos Lazic, Pierre Chambon, Andrιe Krust, Jeffrey Weiss, Deborah J. Clegg, Andrea Dunaif, J. Larry Jameson, Jon E. Levine. Genetic rescue of nonclassical ER-alpha signaling normalizes energy balance in obese Er-alpha-null mutant mice. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI41702

Cite This Page:

Journal of Clinical Investigation. "Selective estrogen signaling key to postmenopausal risk of obesity." ScienceDaily. ScienceDaily, 18 January 2011. <www.sciencedaily.com/releases/2011/01/110118122734.htm>.
Journal of Clinical Investigation. (2011, January 18). Selective estrogen signaling key to postmenopausal risk of obesity. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2011/01/110118122734.htm
Journal of Clinical Investigation. "Selective estrogen signaling key to postmenopausal risk of obesity." ScienceDaily. www.sciencedaily.com/releases/2011/01/110118122734.htm (accessed October 23, 2014).

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