Featured Research

from universities, journals, and other organizations

Selective estrogen signaling key to postmenopausal risk of obesity

Date:
January 18, 2011
Source:
Journal of Clinical Investigation
Summary:
Although the hormone estradiol-17-beta is a key reproductive hormone, it also contributes to the regulation of energy balance and body weight. As a result, estrogen deficiency following menopause is associated with an increased probability of obesity. New research has generated data that suggest it might be possible to develop drugs that selectively reduce the risks of obesity and metabolic disturbances in postmenopausal women.

The hormone estradiol-17-beta is a key reproductive hormone. However, it also contributes to the regulation of energy balance and body weight. As a result, estrogen deficiency following menopause is associated with an increased probability of obesity and increased risk for developing type 2 diabetes.

A team of researchers, led by Jon Levine, at Northwestern University, Evanston, has now generated new insight into the mechanisms by which ER-alpha signaling maintains normal energy balance. Specifically, the team found that nonclassical ER-alpha signaling is key to the effects of estradiol-17-beta on energy balance.

These data lead them to suggest that it might be possible to develop drugs that selectively activate nonclassical ER-alpha signaling to reduce the risks of obesity and metabolic disturbances in postmenopausal women.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Cheryl J. Park, Zhen Zhao, Christine Glidewell-Kenney, Milos Lazic, Pierre Chambon, Andrιe Krust, Jeffrey Weiss, Deborah J. Clegg, Andrea Dunaif, J. Larry Jameson, Jon E. Levine. Genetic rescue of nonclassical ER-alpha signaling normalizes energy balance in obese Er-alpha-null mutant mice. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI41702

Cite This Page:

Journal of Clinical Investigation. "Selective estrogen signaling key to postmenopausal risk of obesity." ScienceDaily. ScienceDaily, 18 January 2011. <www.sciencedaily.com/releases/2011/01/110118122734.htm>.
Journal of Clinical Investigation. (2011, January 18). Selective estrogen signaling key to postmenopausal risk of obesity. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2011/01/110118122734.htm
Journal of Clinical Investigation. "Selective estrogen signaling key to postmenopausal risk of obesity." ScienceDaily. www.sciencedaily.com/releases/2011/01/110118122734.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) — A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) — President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins