Featured Research

from universities, journals, and other organizations

Scientists grow human liver tissue to be used for transplantation

Date:
January 21, 2011
Source:
Wiley - Blackwell
Summary:
A new study reports on the success of growing human liver cells on resorbable scaffolds made from material similar to surgical sutures. Researchers suggest that this liver tissue could be used in place of donor organs during liver transplantation or during the bridge period until a suitable donor is available for patients with acute liver failure.

A new study reports on the success of growing human liver cells on resorbable scaffolds made from material similar to surgical sutures. Researchers suggest that this liver tissue could be used in place of donor organs during liver transplantation or during the bridge period until a suitable donor is available for patients with acute liver failure. Findings of this study appear in the February issue of Liver Transplantation, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases.

Related Articles


As of January 2011, more than 16,000 Americans are on the waiting list to receive a suitable liver according to data from the Organ Procurement and Transplantation Network. Liver cell (hepatocyte) transplantation offers a possible solution in overcoming the organ shortage. In addition, liver cells have excellent regenerative potential making liver cell transplantation a viable therapeutic approach for patients with metabolic defects or fulminant hepatic failure as the native liver is preserved while liver dysfunction may resolve as regeneration occurs.

Dr. Joerg-Matthias Pollok, Head of the Laboratory for Tissue Engineering and Cell Transplantation, Department of Hepatobiliary and Transplantation Surgery at the University Medical Center in Hamburg, Germany explains, "Currently isolated liver cells are used for liver cell transplantation, but these cells suffer during cell isolation and cryopreservation, which is one reason there is limited success with this type of transplant procedure." In applying their tissue engineering approach, the German researchers were able to successfully create new liver tissue providing a potential solution to the obstacles challenging liver cell transplantation.

The team isolated liver cells from 12 human liver specimens with a viability of 82%. After a two-day culture period, liver cells formed tightly packed cellular aggregates, called spheroids, and took on a liver-like appearance. Human liver cells were distributed across a three-dimensional porous structure of the polymer scaffolding. From day two to four, the average number of spheroids more than doubled from 18 to 41 per visual field. "Our experimental model represents a promising technique to culture human liver cells and prepare them for transplantation on a biodegradable polymer scaffold into the peritoneal cavity," concluded Dr. Pollok. "Further studies are underway to confirm our results and may ultimately offer viable clinical options for liver cell transplantation in the future."

A related editorial also published in Liver Transplantation this month acknowledges the huge clinical potential for liver cell transplantation. Humphrey Hodgson, M.D., from the UCL Medical School in London wrote that a number of liver cell transplantation approaches have been used in uncontrolled trials, but effective clinical protocols have not yet been established. He noted that while no technique has emerged as a proven clinical approach, the use of human rather than rodent cells as demonstrated by Pollok et al. is an important step in advancing the science behind liver cell transplantation.


Story Source:

The above story is based on materials provided by Wiley - Blackwell. Note: Materials may be edited for content and length.


Journal References:

  1. Eva Tφrφk, Marc Lutgehetmann, Jeanette Bierwolf, Stefan Melbeck, Jochen Dόllmann, Bjoern Nashan, Peter X. Ma, Joerg M. Pollok. Primary human hepatocytes on biodegradable PLLA-matrices: A promising model for improving transplantation efficiency using tissue engineering. Liver Transplantation, 2010; DOI: 10.1002/lt.22200
  2. Humphrey Hodgson, Clare Selden. Liver cell implants - a long road. Liver Transplantation, 2010; DOI: 10.1002/lt.22245

Cite This Page:

Wiley - Blackwell. "Scientists grow human liver tissue to be used for transplantation." ScienceDaily. ScienceDaily, 21 January 2011. <www.sciencedaily.com/releases/2011/01/110120085521.htm>.
Wiley - Blackwell. (2011, January 21). Scientists grow human liver tissue to be used for transplantation. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2011/01/110120085521.htm
Wiley - Blackwell. "Scientists grow human liver tissue to be used for transplantation." ScienceDaily. www.sciencedaily.com/releases/2011/01/110120085521.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) — Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) — The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) — Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) — Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins