Featured Research

from universities, journals, and other organizations

Fighting the fight for healthy teeth

Date:
January 24, 2011
Source:
BioMed Central
Summary:
It is known that teeth can protect themselves, to some extent, from attack by bacteria but that inflammation within a tooth can be damaging and, in extreme cases, lead to abscess or death of the tooth. New research shows that odontoblast cells are part of the immune system and fight to protect teeth from decay.

It is known that teeth can protect themselves, to some extent, from attack by bacteria but that inflammation within a tooth can be damaging and, in extreme cases, lead to abscess or death of the tooth. New research published in BioMed Central's open access journal BMC Immunology shows that odontoblast cells are part of the immune system and fight to protect teeth from decay.

Related Articles


Inside a tooth odontoblast cells sit between the enamel and pulp and produce a layer of dentin to protect the pulp from wear and infection. This research shows that, when under attack from bacteria, the odontoblast cells also orchestrate an immune response, producing antimicrobial peptides (β-defensins) to fight the infection directly, protein messengers (chemokines) which recruit white blood cells to the site of infection, and pro-inflammatory signalling proteins (IL-1β, IL-1α, and TNF-α) which, in turn, initiate an inflammatory response.

Dr Orapin Horst also found that the odontoblast layer produced proteins involved in the down-regulation of this inflammatory response, such as toll-interacting protein (TOLLIP), TGF-β, and IL-10, which help protect the underlying pulp from inflammatory damage.

Dr Horst says that "For the first time we now have targets to control irreversible inflammatory damage to teeth."


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Orapin V. Horst, Jeremy A. Horst, Ram Samudrala, Beverly A. Dale. Caries Induced Cytokine Network in the Odontoblast Layer of Human Teeth. BMC Immunology, (in press) [link]

Cite This Page:

BioMed Central. "Fighting the fight for healthy teeth." ScienceDaily. ScienceDaily, 24 January 2011. <www.sciencedaily.com/releases/2011/01/110123210113.htm>.
BioMed Central. (2011, January 24). Fighting the fight for healthy teeth. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2011/01/110123210113.htm
BioMed Central. "Fighting the fight for healthy teeth." ScienceDaily. www.sciencedaily.com/releases/2011/01/110123210113.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins