Featured Research

from universities, journals, and other organizations

New way to prevent infections in dialysis patients

Date:
January 26, 2011
Source:
University of Calgary
Summary:
Researchers have discovered that a drug used to treat dialysis catheter malfunction in kidney dialysis patients may now also help prevent both malfunction as well as infections.

Researchers have discovered that a drug used to treat dialysis catheter malfunction in kidney dialysis patients may now also help prevent both malfunction as well as infections.

Dr. Brenda Hemmelgarn from the University of Calgary Faculty of Medicine and her colleague Dr. Nairne Scott-Douglas, both members of the Libin Cardiovascular Institute of Alberta, undertook a randomized trial at 11 sites across Canada. 115 hemodialysis patients were administered the usual catheter locking solution of heparin after every dialysis session, while 110 patients received rt-PA once a week. Researchers found that those receiving only heparin were twice as likely to suffer a catheter malfunction and were at an almost three-fold increased risk of blood stream infection.

"We now have evidence that we can prevent these complications using rt-PA, with a goal to ultimately improve outcomes for patients with kidney failure," says Hemmelgarn.

Didja Nawolsky knows the importance of avoiding infection. In 2003 her kidney failed and she has been on dialysis ever since. She has had 15 permanent and temporary catheters and her constant concern is avoiding infections.

"An infection can easily get into my blood stream and cause serious problems. The line also has to be removed and replaced when there is an infection, which is a rather unpleasant experience I prefer to avoid. This research will benefit myself and others using catheters because it reduces infections, which is hugely important," she says.

Patients with kidney failure undergo hemodialysis, a treatment used to clean their blood. A catheter placed into the blood system is often required to undertake the hemodialysis procedure. However, there are often complications with the dialysis catheter known as 'catheter malfunction' that involve blood clots forming at the catheter tip, as well as infections in the blood stream. Heparin is used as a locking solution in the catheter after dialysis to help prevent malfunction, and keep the dialysis catheter working for a longer period of time.

"Given the considerable cost of blood infections and catheter malfunction physicians should consider using r-TPA prohylactically to prevent these complications in higher risk patients," says Scott-Douglas.

These research findings are published in the January 26th edition of the New England Journal of Medicine.


Story Source:

The above story is based on materials provided by University of Calgary. Note: Materials may be edited for content and length.


Journal Reference:

  1. Brenda R. Hemmelgarn, Louise M. Moist, Charmaine E. Lok, Marcello Tonelli, Braden J. Manns, Rachel M. Holden, Martine LeBlanc, Peter Faris, Paul Barre, Jianguo Zhang, Nairne Scott-Douglas. Prevention of Dialysis Catheter Malfunction with Recombinant Tissue Plasminogen Activator. New England Journal of Medicine, 2011; 364 (4): 303 DOI: 10.1056/NEJMoa1011376

Cite This Page:

University of Calgary. "New way to prevent infections in dialysis patients." ScienceDaily. ScienceDaily, 26 January 2011. <www.sciencedaily.com/releases/2011/01/110126171454.htm>.
University of Calgary. (2011, January 26). New way to prevent infections in dialysis patients. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2011/01/110126171454.htm
University of Calgary. "New way to prevent infections in dialysis patients." ScienceDaily. www.sciencedaily.com/releases/2011/01/110126171454.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins