Featured Research

from universities, journals, and other organizations

Celiac disease and Crohn's disease share part of their genetic background

Date:
January 30, 2011
Source:
Public Library of Science
Summary:
An investigation has found that celiac disease and Crohn's disease, both inflammatory diseases of the gastrointestinal tract, share at least four genetic risk loci. Researchers performed a combined meta-analysis of genome-wide data for celiac disease and Crohn's disease. This meta-analysis has identified two new shared risk loci and two shared risk loci that had previously been independently identified for each disease.

An investigation has found that celiac disease and Crohn's disease, both inflammatory diseases of the gastrointestinal tract, share at least four genetic risk loci. Together, researchers from the University of Groningen, The Netherlands; the Broad Institute, USA; the Université de Montréal and Montreal Heart Institute in Canada performed a combined meta-analysis of genome-wide data for celiac disease and Crohn's disease. This meta-analysis, published in the open-access journal PLoS Genetics on January 27, has identified two new shared risk loci and two shared risk loci that had previously been independently identified for each disease.

The pathogenesis of both celiac disease and Crohn's disease is only partly understood, although it is known that they are affected by both genetic and environmental risk factors. At least one in every hundred individuals in the Western world develop celiac disease; Crohn's disease is much less common but can be accompanied by more severe symptoms as it can affect the whole gastrointestinal tract. Celiac patients develop an inflammation of the small bowel in reaction to gluten, whereas there is no specific known autoantigen for Crohn's disease.

However, the primary cause of Crohn's disease is thought to be a dysregulated immune response to gut bacteria. In order to gain a better understanding of the pathogenesis and to aid in developing therapies against these disorders, knowledge of the genetic background of the diseases is vital.

As it has previously been shown that celiac patients are at a higher risk of developing Crohn's disease than non-sufferers, it had been thought that the two illnesses would share genetic risk loci. This study combined the results from the genetic investigations into both diseases to show that part of the genetic background of Crohn's disease and celiac disease is shared, which confirms a common pathogenesis for these disorders. Although additional studies will be necessary to understand the mechanisms by which these variants influence both Crohn's disease and celiac, the current study provides a proof of principle that risk factors shared across related diseases can be identified by directly combining genetic data from clinically distinct diseases.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Eleonora A. M. Festen, Philippe Goyette, Todd Green, Gabrielle Boucher, Claudine Beauchamp, Gosia Trynka, Patrick C. Dubois, Caroline Lagacé, Pieter C. F. Stokkers, Daan W. Hommes, Donatella Barisani, Orazio Palmieri, Vito Annese, David A. van Heel, Rinse K. Weersma, Mark J. Daly, Cisca Wijmenga, John D. Rioux. A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease. PLoS Genetics, 2011; 7 (1): e1001283 DOI: 10.1371/journal.pgen.1001283

Cite This Page:

Public Library of Science. "Celiac disease and Crohn's disease share part of their genetic background." ScienceDaily. ScienceDaily, 30 January 2011. <www.sciencedaily.com/releases/2011/01/110127205840.htm>.
Public Library of Science. (2011, January 30). Celiac disease and Crohn's disease share part of their genetic background. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2011/01/110127205840.htm
Public Library of Science. "Celiac disease and Crohn's disease share part of their genetic background." ScienceDaily. www.sciencedaily.com/releases/2011/01/110127205840.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) — Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) — California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) — The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins