Featured Research

from universities, journals, and other organizations

Deadly tool discovered in Salmonella's bag of tricks

Date:
February 4, 2011
Source:
Yale University
Summary:
The potentially deadly bacterium Salmonella possesses a molecular machine that marshals the proteins it needs to hijack cellular mechanisms and infect millions worldwide. Researchers have discovered how Salmonella, a major cause of food poisoning and typhoid fever, is able to make these proteins line in up in just the right sequence to invade host cells.

This is a surface rendering of the structure of type III secretion needle complex, which is used by Salmonella to infect cells.
Credit: Thomas Marlovits/Courtesy of Yale University

The potentially deadly bacterium Salmonella possesses a molecular machine that marshals the proteins it needs to hijack cellular mechanisms and infect millions worldwide.

Related Articles


In a paper published Feb. 3 online in Science Express, Yale University researchers describe in detail how Salmonella, a major cause of food poisoning and typhoid fever, is able to make these proteins line in up in just the right sequence to invade host cells.

"These mechanisms present us with novel targets that might form the basis for the development of an entirely new class of anti-microbials," said Jorge Galan, senior author of the paper and the Lucille P. Markey Professor of Microbial Pathogenesis and chair of the Section of Microbial Pathogenesis at Yale.

Galan's lab has been in the forefront of investigating the intricate mechanisms that microbes such as Salmonella use to infect foreign cells. In the new study, Galan and colleagues identify what they call a bacterial sorting platform, which attracts needed proteins and lines them up in a specific order. If the proteins do not line up properly, Salmonella, as well as many other bacterial pathogens, cannot "inject" them into host cells to commandeer host cell functions, the lab has found.

Understanding how this machine works raises the possibility that new therapies can be developed which disable this protein delivery machine and therefore thwart the ability of the bacterium to become pathogenic. This process would not kill the bacteria as most antibiotics do, but would cripple its ability to do harm.

In theory, this means that bacteria such as Salmonella might not develop resistance to new therapies as quickly as they usually do to conventional antibiotics.

Salmonella sickens at least 40,000 people annually in the United States and kills about 400 people, according to the Centers for Disease Control.

Other Yale authors of the paper are Maria Lara-Tejero, Junya Kato, Samuel Wagner and Xiaoyun Liu.

The National Institutes of Health funded the study.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Marνa Lara-Tejero, Junya Kato, Samuel Wagner, Xiaoyun Liu, and Jorge E. Galαn. A Sorting Platform Determines the Order of Protein Secretion in Bacterial Type III Systems. Science, 3 February 2011 DOI: 10.1126/science.1201476

Cite This Page:

Yale University. "Deadly tool discovered in Salmonella's bag of tricks." ScienceDaily. ScienceDaily, 4 February 2011. <www.sciencedaily.com/releases/2011/02/110203141816.htm>.
Yale University. (2011, February 4). Deadly tool discovered in Salmonella's bag of tricks. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2011/02/110203141816.htm
Yale University. "Deadly tool discovered in Salmonella's bag of tricks." ScienceDaily. www.sciencedaily.com/releases/2011/02/110203141816.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Feast Your Eyes: Lamb Chop Sent Into Space from UK

Feast Your Eyes: Lamb Chop Sent Into Space from UK

Reuters - Light News Video Online (Nov. 25, 2014) — Take a stab at this -- stunt video shows a lamb chop's journey from an east London restaurant over 30 kilometers into space. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Cambodian Capital's Only Working Elephant to Retire in Jungle

Cambodian Capital's Only Working Elephant to Retire in Jungle

AFP (Nov. 25, 2014) — Phnom Penh's only working elephant was blessed by a crowd of chanting Buddhist monks Tuesday as she prepared for a life of comfortable jungle retirement after three decades of giving rides to tourists. Duration: 00:36 Video provided by AFP
Powered by NewsLook.com
Stray Dog Follows Adventure Racing Team for 6-Day Endurance Race

Stray Dog Follows Adventure Racing Team for 6-Day Endurance Race

Buzz60 (Nov. 24, 2014) — A Swedish Adventure racing team travels to try and win a world title, but comes home with something way better: a stray dog that joined the team for much of the grueling 430-mile race. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins