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Urine-sniffing dogs: Early detection of prostate cancer

Date:
February 8, 2011
Source:
Elsevier
Summary:
Researchers report the evaluation of the efficacy of prostate cancer (PCa) detection by trained dogs on human urine samples.

In the February 2011 issue of European Urology, Jean-Nicolas Cornu and colleagues reported the evaluation of the efficacy of prostate cancer (PCa) detection by trained dogs on human urine samples.

In their article, the researchers affirm that volatiles organic compounds (VOCs) in urine have been proposed as cancer biomarkers. In the study, a Belgian Malinois shepherd was trained by the clicker training method (operant conditioning) to scent and recognize urine of people having PCa. All urine samples were frozen for preservation and heated to the same temperature for all tests. After a learning phase and a training period of 24 months, the dog's ability to discriminate PCa and control urine was tested in a double-blind procedure.

Urine was obtained from 66 patients referred to an urologist for elevated prostate-specific antigen or abnormal digital rectal examination. All patients underwent prostate biopsy and two groups were considered: 33 patients with cancer and 33 controls presenting negative biopsies. The dog completed all the runs and correctly designated the cancer samples in 30 of 33 cases. Of the three cases wrongly classified as cancer, one patient was re-biopsied and a PCa was diagnosed. The sensitivity and specificity were both 91%.

This study shows that dogs can be trained to detect PCa by smelling urine with a significant success rate. It also suggests that PCa gives an odor signature to urine. Identification of the VOCs involved could lead to a potentially useful screening tool for PCa.


Story Source:

The above story is based on materials provided by Elsevier. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jean-Nicolas Cornu, Gιraldine Cancel-Tassin, Valιrie Ondet, Caroline Girardet, Olivier Cussenot. Olfactory Detection of Prostate Cancer by Dogs Sniffing Urine: A Step Forward in Early Diagnosis. European Urology, 2011; 59 (2): 197 DOI: 10.1016/j.eururo.2010.10.006

Cite This Page:

Elsevier. "Urine-sniffing dogs: Early detection of prostate cancer." ScienceDaily. ScienceDaily, 8 February 2011. <www.sciencedaily.com/releases/2011/02/110207103525.htm>.
Elsevier. (2011, February 8). Urine-sniffing dogs: Early detection of prostate cancer. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2011/02/110207103525.htm
Elsevier. "Urine-sniffing dogs: Early detection of prostate cancer." ScienceDaily. www.sciencedaily.com/releases/2011/02/110207103525.htm (accessed September 2, 2014).

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