Featured Research

from universities, journals, and other organizations

Border patrol: Immune cells protect body from invaders

Date:
February 9, 2011
Source:
University of Pennsylvania School of Medicine
Summary:
Barrier sites -- the skin, gut, lung -- limit the inner body's exposure to allergens, pollutants, viruses, bacteria, and parasites. Understanding how the immune system works in these external surfaces has implications for understanding such inflammatory diseases as asthma, psoriasis, IBD, and food allergies, all of which occur at the body's barriers. Researchers have identified an immune cell population that acts as the body's border patrol with the outside world.

Color-enhanced tissue section from colon of a C. rodentium-infected mouse that displays intestinal inflammation characterized by inflammatory cell infiltrates and crypt elongation.
Credit: Gregory F. Sonnenberg, University of Pennsylvania School of Medicine

So-called barrier sites -- the skin, gut, lung -- limit the inner body's exposure to allergens, pollutants, viruses, bacteria, and parasites. Understanding how the immune system works in these external surfaces has implications for understanding such inflammatory diseases as asthma, psoriasis, IBD, and food allergies, all of which occur at the body's barriers.

Related Articles


David Artis, PhD, professor of Microbiology at the University of Pennsylvania School of Medicine, and Gregory F. Sonnenberg, a predoctoral fellow in the Artis lab, have identified an immune cell population that acts as the body's border patrol with the outside world. They discovered that these lymphoid tissue inducer cells maintain immunity in the intestine of mice. The research appeared in the most recent online issue of Immunity.

Following infection by Citrobacter rodentium -- a model of human E. coli infection in the gut -- this cell population was the dominant source of IL-22, a molecule that helps in the immune response during the early phases of infection. When the inducer cells were eliminated from the intestine of the experimental mice, immunity was impaired, affecting the production of anti-microbial proteins required to fight infection. The mice eventually died.

This discovery could also represent a new line of research for HIV/AIDS, says Artis, since there is a breakdown of barrier immunity in the gut (a reservoir for HIV) that can lead to full blown AIDS. Therapeutics to target such immune cells could be an important new way to combat AIDS.

The research was funded by the National Institute of Allergy and Infectious Diseases, the Burroughs Welcome Fund, and the Crohn's and Colitis Foundation of America.


Story Source:

The above story is based on materials provided by University of Pennsylvania School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gregory F. Sonnenberg, Laurel A. Monticelli, M. Merle Elloso, Lynette A. Fouser, David Artis. CD4 Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the Gut. Immunity, 2011; 34 (1): 122 DOI: 10.1016/j.immuni.2010.12.009

Cite This Page:

University of Pennsylvania School of Medicine. "Border patrol: Immune cells protect body from invaders." ScienceDaily. ScienceDaily, 9 February 2011. <www.sciencedaily.com/releases/2011/02/110207142621.htm>.
University of Pennsylvania School of Medicine. (2011, February 9). Border patrol: Immune cells protect body from invaders. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2011/02/110207142621.htm
University of Pennsylvania School of Medicine. "Border patrol: Immune cells protect body from invaders." ScienceDaily. www.sciencedaily.com/releases/2011/02/110207142621.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins