Featured Research

from universities, journals, and other organizations

Use of 17-hydroxyprogesterone doesn't reduce rate of preterm delivery or complications in twins, study suggests

Date:
February 10, 2011
Source:
Society for Maternal-Fetal Medicine
Summary:
The use of the hormone 17-Hydroxyprogesterone does not reduce the rate of preterm delivery or neonatal complications in twins, study suggests.

In a study to be presented February 10 at the Society for Maternal-Fetal Medicine's (SMFM) annual meeting, The Pregnancy Meeting ™, in San Francisco, researchers will present findings that show that the use of the hormone 17-Hydroxyprogesterone does not reduce the rate of preterm delivery or neonatal complications in twins.

The hormone 17-Hydroxyprogesterone is sometimes used to reduce the risk of preterm labor. In 2008, the American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine issued an opinion that further studies were needed and that "based on current knowledge, it is important to offer progesterone for pregnancy prolongation to only women with a documented history of a previous spontaneous birth at less than 37 weeks of gestation."

"We chose to study the effects of progesterone on twin pregnancies since that group is at a high risk of preterm delivery and we are always looking for something that will reduce those risks," said C. Andrew Combs, M.D., one of the study's authors.

Combs and his colleagues conducted a placebo-controlled, double-blind, multicenter, randomized clinical trial. Mothers with diamnioticdichorionic twins were randomized to 17-alpha-hydroxyxprogesterone caproate (17P) (250 mg IM) or placebo (castor oil vehicle, 1 mL), starting at 16-23 weeks gestational age (GA), repeated weekly until 34 weeks GA. A sample size of 240 mothers (480 babies) was calculated to give 80% power to detect reduction of composite neonatal morbidity from 45% with placebo to 30% with 17P.

One hundred and sixty mothers were randomized to 17P, 80 to placebo at mean GA of 20 weeks. The results showed that Baseline characteristics were similar between the groups. There was no significant difference in composite neonatal morbidity (14% with 17P vs. 12% with placebo), or in mean GA at delivery (35.3 wks vs. 35.9 wks), delivery < 28 wks (2% vs. 1%), < 32 wks (9% vs. 5%), < 35 wks (33% vs. 26%). There were no perinatal deaths in the 17P group and three neonatal deaths in the placebo group, two after withdrawal of life support because of fetal anomalies not discovered prenatally and one attributed to neonatal sepsis.

The study concludes that the use of 17P in twin pregnancies did not reduce the rate of preterm delivery or neonatal morbidity.

"We also noted that contrary to our previous study that showed an increased risk of pregnancy loss in triplet pregnancies treated with 17P, we had no deaths in the twins treated with 17P," said Combs. "However more studies are needed and it is clear that 17P should only be used with specific high risk pregnancy groups."


Story Source:

The above story is based on materials provided by Society for Maternal-Fetal Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Society for Maternal-Fetal Medicine. "Use of 17-hydroxyprogesterone doesn't reduce rate of preterm delivery or complications in twins, study suggests." ScienceDaily. ScienceDaily, 10 February 2011. <www.sciencedaily.com/releases/2011/02/110210080231.htm>.
Society for Maternal-Fetal Medicine. (2011, February 10). Use of 17-hydroxyprogesterone doesn't reduce rate of preterm delivery or complications in twins, study suggests. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2011/02/110210080231.htm
Society for Maternal-Fetal Medicine. "Use of 17-hydroxyprogesterone doesn't reduce rate of preterm delivery or complications in twins, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/02/110210080231.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins