Featured Research

from universities, journals, and other organizations

Early signs of heart disease in preadolescent children with type 1 diabetes

Date:
February 14, 2011
Source:
Medical College of Wisconsin
Summary:
Cardiovascular disease is the leading cause of death in patients with diabetes. Patients with type 1 diabetes have a 200 percent to 400 percent greater chance of developing cardiovascular disease than those without diabetes. Researchers have now discovered that the early signs of cardiovascular disease are likely to manifest before the onset of puberty in many children with diabetes.

Cardiovascular disease is the leading cause of death in patients with diabetes. Patients with type 1diabetes have a 200 percent to 400 percent greater chance of developing cardiovascular disease than those without diabetes. Medical College of Wisconsin researchers at Children's Hospital of Wisconsin discovered the early signs of cardiovascular disease are likely to manifest before the onset of puberty in many children with diabetes.

Those findings are published in the February 2, 2011 online version of Diabetes Care and will be in the March 2011 issue of Diabetes Care.

Led by Dr. Ramin Alemzadeh, professor of pediatrics at the college and pediatric endocrinologist at Children's Hospital of Wisconsin, and Senior Clinician Scientist at Children's Hospital's Max McGee Juvenile Diabetes Research Center, the researchers studied 21 preadolescent children (avg. age 8.5 years) with type 1 diabetes, and compared that group to 15 healthy siblings. Investigators looked at flow-mediated dilatation (FMD), a gauge of the health of a major blood vessel of the upper arm artery, in both groups. FMD percentage (FMD%,) is a way to measure any stiffening of the blood vessels; stiffening blood vessels is an early precursor of cardiovascular disease.

Children who had high blood pressure, family history of high cholesterol or premature cardiovascular disease from other causes were excluded. Blood samples were collected from all participants to monitor cholesterol and sugar levels.

When tested, the blood vessels of children with type 1 diabetes had a lower FMD% change, which means their blood vessels were less expandable than the control group suggesting that higher circulating glucose results in increased rigidity of blood vessels independent of serum cholesterol levels. The patients with diabetes also had vascular inflammation, which is a known harbinger of future cardiovascular risk. Long-term studies are needed to evaluate the progression of those vascular changes through puberty and beyond.


Story Source:

The above story is based on materials provided by Medical College of Wisconsin. Note: Materials may be edited for content and length.


Journal Reference:

  1. G. S. Babar, H. Zidan, M. E. Widlansky, E. Das, R. G. Hoffmann, M. Daoud, R. Alemzadeh. Impaired Endothelial Function in Preadolescent Children With Type 1 Diabetes. Diabetes Care, 2011; DOI: 10.2337/dc10-2134

Cite This Page:

Medical College of Wisconsin. "Early signs of heart disease in preadolescent children with type 1 diabetes." ScienceDaily. ScienceDaily, 14 February 2011. <www.sciencedaily.com/releases/2011/02/110214155501.htm>.
Medical College of Wisconsin. (2011, February 14). Early signs of heart disease in preadolescent children with type 1 diabetes. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2011/02/110214155501.htm
Medical College of Wisconsin. "Early signs of heart disease in preadolescent children with type 1 diabetes." ScienceDaily. www.sciencedaily.com/releases/2011/02/110214155501.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins