Featured Research

from universities, journals, and other organizations

Gene expression to distinguish metastasizing from non-metastasizing head and neck cancers

Date:
February 24, 2011
Source:
European Society for Medical Oncology
Summary:
The validation of a test, based on gene expression and predicting the tumors that will metastasize in lymph nodes of head and neck cancers, was recently done. The test correctly predicted the absence of metastasis in 89% of the cases.

The validation of a test, based on gene expression and predicting the tumours that will metastasize in lymph nodes of head & neck cancers, was presented February 24 at the 3rd International Conference on innovative approaches in Head and Neck Oncology (ICHNO), in Barcelona.

Dr Robert Takes, from the Radboud University Nijmegen Medical Centre, the Netherlands, reported results of a study involving 222 cases of oral or oropharyngeal cancer. The study was jointly led by scientists from Nijmegen and the University Medical Center Utrecht, and involved all eight head and neck oncological centres of the Netherlands.

"Today, it is impossible with current diagnostic tools to detect small lymph node metastasis in patients with head and neck squamous cell carcinoma and therefore it is common practice to operate on the neck even if no metastases have been detected," said Dr Takes. "The majority of these operations is unnecessary because, in most cases, no metastases are present."

If the chance of metastasis could be predicted more accurately, the number of operations could be reduced. "In our study, determining gene expression changes in the primary tumour improved the distinction between tumours that do metastasize from those that don't," continued Dr Takes.

With an array containing a set of 825 relevant genes, identified in a prior study and suitable for clinical application, distinction between metastasizing and non-metastasizing tumours was possible. The test correctly predicted the absence of metastasis in 89% of the cases.

"This is the first biological test that was able to obtain a high level of accuracy and has been validated in multiple centres on a large cohort of patients," said Dr Takes.

"The possible reduction of unnecessary neck treatments in case of a negative test may result in decreased morbidity without deterioration of oncological outcomes. Also, in the remaining cases that still develop metastasis in the neck, salvage treatment is still possible," added Dr Takes.

This signature is an additional method to already existing means to assess the neck, like imaging techniques and sentinel node procedures. "One important message arising from the study is that the combination of biological (gene signature) and clinical factors did better than either alone," commented Prof Adrian Begg from the Netherlands Cancer Institute (NKI). "It thus appears that this signature is a useful addition which can help the decision on treatment policy."

"Treatment is usually mainly selected based on the anatomical extent of the primary tumour and its metastasis. Additional biological information on the behaviour of each individual tumour could result in a more tailored treatment resulting in better survival," said Dr Takes.

"Takes and colleagues have carried out an important and essential step in all studies on gene signatures," concluded Prof Begg, "namely to move on from the initial finding of potential prognostic or predictive significance to validation in an independent clinical series."

"We look forward to further validation and refinement of this approach which opens promising developments. In such studies it would still be useful to look at genome-wide expression, which would provide the opportunity to not only validate the present signature but also to look for even better ones."


Story Source:

The above story is based on materials provided by European Society for Medical Oncology. Note: Materials may be edited for content and length.


Cite This Page:

European Society for Medical Oncology. "Gene expression to distinguish metastasizing from non-metastasizing head and neck cancers." ScienceDaily. ScienceDaily, 24 February 2011. <www.sciencedaily.com/releases/2011/02/110224121857.htm>.
European Society for Medical Oncology. (2011, February 24). Gene expression to distinguish metastasizing from non-metastasizing head and neck cancers. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2011/02/110224121857.htm
European Society for Medical Oncology. "Gene expression to distinguish metastasizing from non-metastasizing head and neck cancers." ScienceDaily. www.sciencedaily.com/releases/2011/02/110224121857.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins