Featured Research

from universities, journals, and other organizations

Heparin a key role player in allergy and inflammatory reactions

Date:
February 27, 2011
Source:
Karolinska Institutet
Summary:
Heparin plays a key role in allergic and inflammatory reactions driven by mast cells, scientists show. The study sheds some new light on the biological function of heparin.

Heparin plays a key role in allergic and inflammatory reactions driven by mast cells, scientists from Karolinska Institutet in Sweden shows in an international collaboration involving colleagues from Germany and Switzerland. The study is published in the recent issue of Immunity, and sheds some new light on the biological function of heparin.

Related Articles


Heparin has a long history at Karolinska Institutet, since here the substance was originally purified and its chemical structure was characterized back in 1935 by Professor Erik Jorpes. Knowing about the therapeutic implications Jorpes was one of the pioneers treating patients that suffered from thrombosis with heparin infusions. Today, heparin is still one of the most commonly used anticoagulant drugs.

Professor Jorpes showed that heparin is produced in a specific blood-born cell population, called mast cells. Mast cells have a central function in allergic and inflammatory diseases and contribute to increased vascular permeability, allergic and anaphylactic reactions. The current study identifies the underlying mechanism and its therapeutical implications. The authors show that heparin initiates the production of a hormone -- bradykinin -- that contributes to swelling, anaphylactic and inflammatory symptoms, which are commonly known to be associated with aberrant mast cell activity.

Notably, mast cell-released heparin generates the inflammatory mediator bradykinin via activation of factor XII (the so-called Hageman Factor) that belongs to the blood coagulation system. The study thus provides an unexpected link between the clotting cascade and mast cell-driven pro-inflammatory reactions. Drugs that block bradykinin or factor XII activity protect from adverse mast cell-driven effects in patients and genetically engineered mouse models and could be a new strategy to treat allergic diseases.


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chris Oschatz, Coen Maas, Bernd Lecher, Thomas Jansen, Jenny Björkqvist, Thomas Tradler, Reinhard Sedlmeier, Peter Burfeind, Sven Cichon, Sven Hammerschmidt, Werner Müller-Esterl, Walter A. Wuillemin, Gunnar Nilsson, and Thomas Renné. Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo. Immunity, February 25, 2011, Volume 34, Issue 2

Cite This Page:

Karolinska Institutet. "Heparin a key role player in allergy and inflammatory reactions." ScienceDaily. ScienceDaily, 27 February 2011. <www.sciencedaily.com/releases/2011/02/110225090848.htm>.
Karolinska Institutet. (2011, February 27). Heparin a key role player in allergy and inflammatory reactions. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2011/02/110225090848.htm
Karolinska Institutet. "Heparin a key role player in allergy and inflammatory reactions." ScienceDaily. www.sciencedaily.com/releases/2011/02/110225090848.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins