Featured Research

from universities, journals, and other organizations

Scientists generate pluripotent stem cells from horses

Date:
February 28, 2011
Source:
University of Montreal
Summary:
Pluripotent stem cells have now been generated from horses. The findings will help enable new stem-cell based regenerative therapies in veterinary medicine, and because horses' muscle and tendon systems are similar to our own, aid the development of preclinical models leading to human applications.

In a world first, pluripotent stem cells have been generated from horses.
Credit: iStockphoto/Stanislav Fadyukhin

In a world first, pluripotent stem cells have been generated from horses by a team of researchers led by Dr. Andras Nagy at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital and Dr. Lawrence Smith at the University of Montreal's Faculty of Veterinary Science. The findings will help enable new stem-cell based regenerative therapies in veterinary medicine, and because horses' muscle and tendon systems are similar to our own, aid the development of preclinical models leading to human applications.

Related Articles


The study was published in the February 28 issue of the leading journal Stem Cell Reviews and Reports.

These induced pluripotent stem (iPS) cells can develop into most other cell types and are a source of great hope for use in regenerative medicine and the development of new drugs to prevent and treat various illnesses. One aspect of regenerative medicine is the process of creating living, functional tissues to repair or replace tissue or organ function lost due to damage or disease. "To date, iPS cells have been established from several species, but our study is the first to report the derivation of these changeable cells from horses," Dr. Smith explained.

The research represents a breakthrough for both human and animal health alike. "Equine iPS cells bring new therapeutic potential to the veterinary field, and open up the opportunity to validate stem-cell based therapies before clinical studies in humans," Dr. Nagy said. "As well, stem-cell based studies using the horse as a model more closely replicate human illnesses, when compared with studies in mice."

After two months of reprogramming equine somatic cells, the resulting iPS cell lines expressed hallmark markers of pluripotency, contained a correct set of horse chromosomes, and were able to form a full spectrum of cell types and tissues fulfilling the criteria of pluripotency. The term pluripotency refers to the ability of a stem cell to become any of the vast number of different cell types found in the body. "This means that the cell lines passed all the tests available to us for determining if they truly are what we think they are: pluripotent and a good source for future regenerative applications," said Kristina Nagy, research associate in the Nagy laboratory and lead author of the study.

"The horse is an excellent model for a range of human degenerative diseases, especially those involving joints, bones, tendons and ligaments, such as arthritis," said Dr. Sheila Laverty, a professor in the Faculty of Veterinary Medicine at the University of Montreal. "Bone fracture, as well as damaged cartilage, tendons and ligaments heal poorly in horses. Therefore, the use of iPS cells in these animals may help enhance long-term tissue repair." Further research will be required to develop clinical treatments.

Dr. Andras Nagy is a senior investigator at the Lunenfeld, the Canada Research Chair in Stem Cells and Regeneration and McEwen investigator. He received support from the Canadian Stem Cell Network of Canada for this research. Dr. Smith is the Canadian Research Chair in Animal Cloning and Stem Cells and received support from the Canadian Arthritis Network. His lab plays a key role in the University of Montreal's Animal Reproduction Research Centre.


Story Source:

The above story is based on materials provided by University of Montreal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kristina Nagy, Hoon-Ki Sung, Puzheng Zhang, Simon Laflamme, Patrick Vincent, Siamak Agha-Mohammadi, Knut Woltjen, Claudio Monetti, Iacovos Prodromos Michael, Lawrence Charles Smith, Andras Nagy. Induced Pluripotent Stem Cell Lines Derived from Equine Fibroblasts. Stem Cell Reviews and Reports, 2011; DOI: 10.1007/s12015-011-9239-5

Cite This Page:

University of Montreal. "Scientists generate pluripotent stem cells from horses." ScienceDaily. ScienceDaily, 28 February 2011. <www.sciencedaily.com/releases/2011/02/110228090232.htm>.
University of Montreal. (2011, February 28). Scientists generate pluripotent stem cells from horses. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2011/02/110228090232.htm
University of Montreal. "Scientists generate pluripotent stem cells from horses." ScienceDaily. www.sciencedaily.com/releases/2011/02/110228090232.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins