Featured Research

from universities, journals, and other organizations

New peptide could be effective treatment for triple negative breast cancer

Date:
March 8, 2011
Source:
Temple University
Summary:
A new leptin receptor antagonist peptide has demonstrated efficacy against triple negative breast cancer.

A new peptide developed by researchers in Temple University's College of Science and Technology has demonstrated efficacy against triple negative breast cancer.

Related Articles


The leptin receptor antagonist peptide, developed by researchers Laszlo Otvos and Eva Surmacz, could become an attractive option for triple negative breast cancer treatment, especially in the obese patient population. The researchers published their findings online in the European Journal of Cancer.

According to the researchers, triple-negative breast cancers -- which represent 10-20 percent of all mammary tumors -- are characterized by the aggressive traits that is often found in younger women and have been associated with poor prognosis.

"Obesity increases the risk for triple-negative breast cancer development," said Surmacz, an associate research professor in biology at Temple. "Because triple-negative breast cancer patients are unresponsive to current targeted therapies and other treatment options are only partially effective, new pharmacological modalities are urgently needed."

Leptin, a protein that is always elevated in obese individuals and is higher in women than in men, can act locally within the body and promote cancer development by inducing the survival and growth of tumor cells, counteracting the effects of cancer therapies, and promoting metastasis. Previous studies by Surmacz suggested that leptin levels are significantly higher in aggressive breast tumors than in normal breast tissue.

In their study, the researchers examined if the leptin receptor was a viable target for the treatment of this type of cancer. It has been shown that in human triple negative breast cancer tissues, the leptin receptor was expressed in 92 percent and leptin in 86 percent of cases.

Using a mouse model of triple negative breast cancer, they tested the new leptin receptor antagonist peptide and compared it to conventional chemotherapy. The leptin receptor antagonist peptide extended the average survival time by 80 percent, compared to 21 percent for chemotherapy. The peptide was found to be non-toxic even up to the highest dose administered, said Sumacz.

"If this peptide, with its advantageous administration route and safety profile, can be developed as a drug it could be a useful addition to the existing oncology drug repertoire against various forms of cancer, including breast, brain, prostate and colon cancers," said Sumacz.

The study was partially funded by the Pennsylvania Department of Health.


Story Source:

The above story is based on materials provided by Temple University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Laszlo Otvos Jr., Ilona Kovalszky, Mirko Riolfi, Rita Ferla, Julia Olah, Andras Sztodola, Kaushik Nama, Annamaria Molino, Quirino Piubello, John D. Wade. Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer. European Journal of Cancer, 2011; DOI: 10.1016/j.ejca.2011.01.018

Cite This Page:

Temple University. "New peptide could be effective treatment for triple negative breast cancer." ScienceDaily. ScienceDaily, 8 March 2011. <www.sciencedaily.com/releases/2011/02/110228151915.htm>.
Temple University. (2011, March 8). New peptide could be effective treatment for triple negative breast cancer. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2011/02/110228151915.htm
Temple University. "New peptide could be effective treatment for triple negative breast cancer." ScienceDaily. www.sciencedaily.com/releases/2011/02/110228151915.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins