Featured Research

from universities, journals, and other organizations

Easy, accurate way to predict food allergies developed, study suggests

Date:
March 3, 2011
Source:
University College Cork
Summary:
An on-line calculator that predicts, within seconds, the presence of the three major food allergies in children has been developed. The new calculator gives 96% accuracy compared to current methods that are 61% -81% accurate.

Dr Audrey DunnGalvin, Department of Early Years and Childhood Studies and Research Fellow with the Department of Paediatrics and Child Health, UCC, Professor Jonathan Hourihane, Department of Paediatrics and Child Health, UCC and Mr Kevin Dalton, Office of Tech Transfer, UCC
Credit: Image courtesy of University College Cork

An online calculator that predicts, within seconds, the presence of the three major food allergies in children has been developed by researchers at University College Cork. They have devised a new 'Cork-Southampton calculator' that gives 96% accuracy compared to current methods that are 61% -81% accurate. The research will be published online March 3 in the journal, Journal of Allergy & Clinical Immunology.

Food allergies have increased over the past decade as has the number of patients and parents seeking diagnosis. Double-blind, placebo-controlled food challenges are the gold standard for diagnosing food allergy, but they are time-consuming, costly and, often, a source of parental and medical fear that a severe allergic reaction (anaphylaxis) might occur during a food challenge. In addition, not all clinical facilities have the staff or resources to carry out high quality food challenges.

The two Cork researchers, Dr Audrey DunnGalvin and Professor Jonathan Hourihane of the Department of Paediatrics and Child Health devised a highly accurate, allergen-specific algorithims for each of the most important food types (cow's milk, egg, peanut). The mathematical model consisted of known or suspected predictors that when combined greatly increased the accuracy of the final model. The researchers reasoned and proved that the more clinical information that could be considered, the more accurate the predictive model would be.

They looked at the outcomes of combinations of data on clinical factors (skin prick test, allergen specific IgE in serum, total IgE, allergic reaction history, sex and age). The researchers then compared those to the results of the children's food challenges. From this analysis, they developed an effective prediction model, a 'calculator' of a positive food challenge that was a more accurate predictor than individual allergy tests.

This new calculator will improve the quality of life of parents and patients (on average seven years old) and will reduce significantly the cost of food allergy tests. "Young children can find the normal food allergy tests quite stressful and this test will take a lot of the distress out of the process, even just by delaying a challenge until the odds of passing it improve over time, which is the norm." says Dr Audrey DunnGalvin. "It has also implications for oral immunotherapy where clinicians try to desensitise children to their allergies by giving them controlled doses of the food to which they are allergic. The Cork-Southampton calculator will help assess appropriate stop/continue/ maintenance points in this treatment."

"Conventional food allergy tests are less than perfect but the UCC patented diagnostic is very reliable and should replace uncertainty with certainty for many doctors treating children with food allergy," says Kevin Dalton of UCC's Office of Technology Transfer. "We foresee a commercial product being launched this year resulting in better patient care and substantial savings for the healthcare service."

Article title: Highly accurate prediction of food challenge outcome using routinely available clinical data


Story Source:

The above story is based on materials provided by University College Cork. Note: Materials may be edited for content and length.


Journal Reference:

  1. L.M. Segal, J.O.B. Hourihane, A. Clarke, R. Alizadehfar, J. Lucas, G. Roberts, M. Lajeunesse, A. DunnGalvin. A Systematic Evaluation of the Cork-Southampton Food Challenge Outcome Calculator in a Canadian Sample. Journal of Allergy and Clinical Immunology, 2011; 127 (2): AB184 DOI: 10.1016/j.jaci.2010.12.732

Cite This Page:

University College Cork. "Easy, accurate way to predict food allergies developed, study suggests." ScienceDaily. ScienceDaily, 3 March 2011. <www.sciencedaily.com/releases/2011/03/110303065400.htm>.
University College Cork. (2011, March 3). Easy, accurate way to predict food allergies developed, study suggests. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2011/03/110303065400.htm
University College Cork. "Easy, accurate way to predict food allergies developed, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/03/110303065400.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins