Featured Research

from universities, journals, and other organizations

Easy, accurate way to predict food allergies developed, study suggests

Date:
March 3, 2011
Source:
University College Cork
Summary:
An on-line calculator that predicts, within seconds, the presence of the three major food allergies in children has been developed. The new calculator gives 96% accuracy compared to current methods that are 61% -81% accurate.

Dr Audrey DunnGalvin, Department of Early Years and Childhood Studies and Research Fellow with the Department of Paediatrics and Child Health, UCC, Professor Jonathan Hourihane, Department of Paediatrics and Child Health, UCC and Mr Kevin Dalton, Office of Tech Transfer, UCC
Credit: Image courtesy of University College Cork

An online calculator that predicts, within seconds, the presence of the three major food allergies in children has been developed by researchers at University College Cork. They have devised a new 'Cork-Southampton calculator' that gives 96% accuracy compared to current methods that are 61% -81% accurate. The research will be published online March 3 in the journal, Journal of Allergy & Clinical Immunology.

Related Articles


Food allergies have increased over the past decade as has the number of patients and parents seeking diagnosis. Double-blind, placebo-controlled food challenges are the gold standard for diagnosing food allergy, but they are time-consuming, costly and, often, a source of parental and medical fear that a severe allergic reaction (anaphylaxis) might occur during a food challenge. In addition, not all clinical facilities have the staff or resources to carry out high quality food challenges.

The two Cork researchers, Dr Audrey DunnGalvin and Professor Jonathan Hourihane of the Department of Paediatrics and Child Health devised a highly accurate, allergen-specific algorithims for each of the most important food types (cow's milk, egg, peanut). The mathematical model consisted of known or suspected predictors that when combined greatly increased the accuracy of the final model. The researchers reasoned and proved that the more clinical information that could be considered, the more accurate the predictive model would be.

They looked at the outcomes of combinations of data on clinical factors (skin prick test, allergen specific IgE in serum, total IgE, allergic reaction history, sex and age). The researchers then compared those to the results of the children's food challenges. From this analysis, they developed an effective prediction model, a 'calculator' of a positive food challenge that was a more accurate predictor than individual allergy tests.

This new calculator will improve the quality of life of parents and patients (on average seven years old) and will reduce significantly the cost of food allergy tests. "Young children can find the normal food allergy tests quite stressful and this test will take a lot of the distress out of the process, even just by delaying a challenge until the odds of passing it improve over time, which is the norm." says Dr Audrey DunnGalvin. "It has also implications for oral immunotherapy where clinicians try to desensitise children to their allergies by giving them controlled doses of the food to which they are allergic. The Cork-Southampton calculator will help assess appropriate stop/continue/ maintenance points in this treatment."

"Conventional food allergy tests are less than perfect but the UCC patented diagnostic is very reliable and should replace uncertainty with certainty for many doctors treating children with food allergy," says Kevin Dalton of UCC's Office of Technology Transfer. "We foresee a commercial product being launched this year resulting in better patient care and substantial savings for the healthcare service."

Article title: Highly accurate prediction of food challenge outcome using routinely available clinical data


Story Source:

The above story is based on materials provided by University College Cork. Note: Materials may be edited for content and length.


Journal Reference:

  1. L.M. Segal, J.O.B. Hourihane, A. Clarke, R. Alizadehfar, J. Lucas, G. Roberts, M. Lajeunesse, A. DunnGalvin. A Systematic Evaluation of the Cork-Southampton Food Challenge Outcome Calculator in a Canadian Sample. Journal of Allergy and Clinical Immunology, 2011; 127 (2): AB184 DOI: 10.1016/j.jaci.2010.12.732

Cite This Page:

University College Cork. "Easy, accurate way to predict food allergies developed, study suggests." ScienceDaily. ScienceDaily, 3 March 2011. <www.sciencedaily.com/releases/2011/03/110303065400.htm>.
University College Cork. (2011, March 3). Easy, accurate way to predict food allergies developed, study suggests. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2011/03/110303065400.htm
University College Cork. "Easy, accurate way to predict food allergies developed, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/03/110303065400.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins