Featured Research

from universities, journals, and other organizations

Patients are willing to undergo multiple tests for new cancer treatments

Date:
March 4, 2011
Source:
The Translational Genomics Research Institute
Summary:
Cancer patients are willing to undergo many tests to receive advanced experimental treatment in clinical trials, according to a new study.

Cancer patients are willing to undergo many tests to receive advanced experimental treatment in clinical trials, according to a new study by Mayo Clinic, Scottsdale Healthcare and the Translational Genomics Research Institute (TGen).

Researchers said patients' willingness to undergo tests bodes well for the future of personalized medicine, in which specific treatments are prescribed depending on the DNA genetic makeup of patients' tumors.

"This is the first study of its kind where patients themselves were asked what tests and medical imaging studies they would be willing to undergo while participating in clinical studies for their cancer. Patients also were asked how invasive they perceived such tests and studies," said Raoul Tibes, M.D. Ph.D., lead author of the study recently published online by the scientific journal Cancer, a physician-scientist for the Mayo Clinic in Arizona.

The study, Patient willingness to undergo pharmacodynamic and pharmacokinetic tests in early phase oncology trials, is scheduled for print publication in the July 15, 2011, edition of Cancer, published by the American Cancer Society.

To learn and understand more about the molecular aspects of cancer, researchers need tumor samples and images from tests like computed tomography (CAT) scans, magnetic resonance imaging (MRIs), positron emission tomography (PET) scans and other tests. Early-phase clinical trials involve analyses of pharmacodynamics (what the drug does to the body) and pharmacokinetics (what the body does to a drug). The authors conducted a prospective study, examining patients' willingness to undergo such tests and the number of tests the patients would tolerate.

"What we learned is that patients are, in general, very willing to undergo additional, extra tests to participate in clinical studies," said Dr. Tibes, a former research doctor for TGen Clinical Research Service, a clinical-trials partnership of TGen and Scottsdale Healthcare at the Virginia G. Piper Cancer Center in Scottsdale.

"This study will provide valuable information, collected from actual patients, thereby informing clinical investigations in an era where we have more and more molecular-targeted therapies available, and our studies are more and more complex," Dr. Tibes said.

The study included 61 patients -- 22 women and 39 men -- with advanced malignancies.

The overall willingness to undergo study-required tests was very high, the study found. Patients were most willing to undergo urine, blood, ultrasound, x-rays, echocardiogram, PET and CAT scan studies. They were least willing to undergo tumor and skin biopsies and MRIs. However, most patients were at lest wiling to give one tumor biopsy sample per study, and often two.

"This is important information, because it tells us that we can design clinical studies that ask patients to give extra tumor biopsies. But we need to carefully judge of how many biopsies we request and what molecular tests we do with the tumor sample," said Mitesh J. Borad, M.D., Associate Director of Phase I Drug Development at the Mayo Clinic in Arizona and the study's senior author.

Inconvenience and prior negative experiences for more invasive tests, such as skin biopsies, modestly affected patients' willingness to undergo these tests again, the study found. Those patients with college educations and insurance coverage were more willing to undergo tests.

Dr. Tibes, who also is Associate Director of Mayo Clinic's Acute and Chronic Leukemia Program, said the study could serve as the basis of further exploration toward the design of patient-friendly, biomarker-driven clinical studies involving cancer.

"We're taking those results forward," said Dr. Tibes, emphasizing the need for similar patient-oriented research, and to clearly communicate and educate patients about their treatment, including the goals of clinical research. "I think we need to hear it from the patients: 'This is what I'm willing to tolerate.' I think we need to ask patients more. It is crucially important."


Story Source:

The above story is based on materials provided by The Translational Genomics Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Raoul Tibes, Barbara F. Piper, Jessica A. Smith, Raysenia L. James, Martin A. Benjamin, Jay H. Yim, Ramesh K. Ramanathan, Daniel D. Von Hoff, R. Curtis Bay, Mitesh J. Borad. Patient willingness to undergo pharmacodynamic and pharmacokinetic tests in early phase oncology trials. Cancer, 2011; DOI: 10.1002/cncr.25885

Cite This Page:

The Translational Genomics Research Institute. "Patients are willing to undergo multiple tests for new cancer treatments." ScienceDaily. ScienceDaily, 4 March 2011. <www.sciencedaily.com/releases/2011/03/110304090457.htm>.
The Translational Genomics Research Institute. (2011, March 4). Patients are willing to undergo multiple tests for new cancer treatments. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2011/03/110304090457.htm
The Translational Genomics Research Institute. "Patients are willing to undergo multiple tests for new cancer treatments." ScienceDaily. www.sciencedaily.com/releases/2011/03/110304090457.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins