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HBV infection decreases risk of liver metastasis in colorectal cancer patients

Date:
March 8, 2011
Source:
World Journal of Gastroenterology
Summary:
A research team from China evaluated the effect of hepatitis B virus (HBV) infection on liver metastasis of colorectal cancer. The study showed that HBV infection decreases the risk of liver metastasis in patients with colorectal cancer and elevates the surgical resection rate of liver metastatic lesions.

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in Western countries. Metastatic liver disease more frequently develops metachronous metastasis following treatment of CRC. It was reported that hepatitis B virus (HBV) infection finally reduces the risk of intrahepatic metastasis in hepatocellular carcinoma (HCC) patients with a higher survival rate and therefore can be considered an important prognostic factor for HCC patients. Rare reports are available on the relation between HBV infection and hepatic metastasis of CRC.

A research article to be published on February 14, 2011 in the World Journal of Gastroenterology addresses this question. The authors designed a cohort study to observe the relation between HBV infection and liver metastasis of CRC.

The results showed a decrease in the percentage of metastases in the Hepatitis B virus infected group (14.2%) with respect to the control group (28.2%). In contrast, the number of patients that developed extrahepatic metastases was significantly higher than the control group, without any significant difference in the overall survival rate.

Finally, the authors suggested that HBV infection in colorectal cancer patients could be used as a prognostic factor in terms of hepatic metastasis formation.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Qiu HB, Zhang LY, Zeng ZL, Wang ZQ, Luo HY, Keshari RP, Zhou ZW, Xu RH. HBV infection decreases risk of liver metastasis in patients with colorectal cancer: A cohort study. World Journal of Gastroenterology, 2011; 17 (6): 804 DOI: 10.3748/wjg.v17.i6.804

Cite This Page:

World Journal of Gastroenterology. "HBV infection decreases risk of liver metastasis in colorectal cancer patients." ScienceDaily. ScienceDaily, 8 March 2011. <www.sciencedaily.com/releases/2011/03/110308101321.htm>.
World Journal of Gastroenterology. (2011, March 8). HBV infection decreases risk of liver metastasis in colorectal cancer patients. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2011/03/110308101321.htm
World Journal of Gastroenterology. "HBV infection decreases risk of liver metastasis in colorectal cancer patients." ScienceDaily. www.sciencedaily.com/releases/2011/03/110308101321.htm (accessed October 2, 2014).

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