Featured Research

from universities, journals, and other organizations

Abnormal neural activity recorded from the deep brain of Parkinson's disease and dystonia patients

Date:
March 10, 2011
Source:
National Institute for Physiological Sciences
Summary:
Scientists have succeeded, for the first time, in recording cortically induced neural activity of the basal ganglia in patients with Parkinson's disease and dystonia during stereotaxic neurosurgery for the deep brain stimulation.

Movement disorders such as Parkinson's diseases and dystonia are caused by abnormal neural activity of the basal ganglia located deep in the brain. The basal ganglia are connected to the cerebral cortex in the brain surface through complex neural circuits. Their basic structure and connections, as well as the dysfunctions in movement disorders, have been examined extensively by using experimental animals. On the other hand, little is known about the human brain that is much more complex in either normal or diseased states.

An international joint research team led by Professor Toru Itakura and Assistant Professor Hiroki Nishibayashi from Wakayama Medical University, Japan, Professor Atsushi Nambu from the National Institute for Physiological Sciences, Japan, and Professor Hitoshi Kita from The University of Tennessee Health Science Center, TN, succeeded, for the first time, in recording cortically induced neural activity of the basal ganglia in patients with Parkinson's disease and dystonia during stereotaxic neurosurgery for the deep brain stimulation (DBS).

This research has been reported in the journal Movement Disorders.

With the consent of patients and based on the ethical guidelines of Wakayama Medical University, the team recorded the neural activity of the globus pallidus, one of the nuclei in the basal ganglia, and examined their activity changes in response to the stimulation of the primary motor cortex. Typical triphasic responses were observed in patients with Parkinson's disease, and enhanced inhibitory responses were observed in a dystonia patient. The results confirmed previous data observed in experimental animals. These results suggest: 1) Cortically evoked neural responses in the basal ganglia can be useful for determining the target location of the DBS electrodes, and 2) Enhanced inhibitory neural responses in the globus pallidus may cause abnormal movements observed in dystonia.

This research was supported by Grants-in-Aid for Scientific Research, from the MEXT, Japan.


Story Source:

The above story is based on materials provided by National Institute for Physiological Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hiroki Nishibayashi, Mitsuhiro Ogura, Koji Kakishita, Satoshi Tanaka, Yoshihisa Tachibana, Atsushi Nambu, Hitoshi Kita, Toru Itakura. Cortically evoked responses of human pallidal neurons recorded during stereotactic neurosurgery. Movement Disorders, 2011; DOI: 10.1002/mds.23502

Cite This Page:

National Institute for Physiological Sciences. "Abnormal neural activity recorded from the deep brain of Parkinson's disease and dystonia patients." ScienceDaily. ScienceDaily, 10 March 2011. <www.sciencedaily.com/releases/2011/03/110309102148.htm>.
National Institute for Physiological Sciences. (2011, March 10). Abnormal neural activity recorded from the deep brain of Parkinson's disease and dystonia patients. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2011/03/110309102148.htm
National Institute for Physiological Sciences. "Abnormal neural activity recorded from the deep brain of Parkinson's disease and dystonia patients." ScienceDaily. www.sciencedaily.com/releases/2011/03/110309102148.htm (accessed July 24, 2014).

Share This




More Mind & Brain News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com
Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins