Featured Research

from universities, journals, and other organizations

Researchers link novel biomarkers to asthma and COPD

Date:
March 21, 2011
Source:
American Thoracic Society
Summary:
Four novel biomarkers have been identified which may aid in the diagnosis and management of asthma and chronic obstructive pulmonary disease, according to a study conducted by researchers in Australia, who determined the biomarkers may be used in different combinations to successfully identify patients with either of the airway diseases. In conducting the study, the researchers relied on proteomics, an emerging field of science that focuses on the structure and functions of an organism's proteins.

Four novel biomarkers have been identified which may aid in the diagnosis and management of asthma and chronic obstructive pulmonary disease (COPD), according to a study conducted by researchers in Australia, who determined the biomarkers may be used in different combinations to successfully identify patients with either of the airway diseases. In conducting the study, the researchers relied on proteomics, an emerging field of science that focuses on the structure and functions of an organism's proteins.

Related Articles


The findings were published online ahead of the print edition of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

"Using a proteomics approach, we have identified a panel of four blood-based biomarkers that, when used in combination, can discriminate between healthy controls, asthmatics and individuals with COPD, and has the potential to be a valuable tool in the clinical diagnosis of respiratory disease," said Peter G. Gibson, MD, conjoint professor at the University of Newcastle's School of Medicine and Public Health. "The proteins in the diagnostic biomarker panel are all involved in the regulation of inflammation, and usually function as anti-inflammatory proteins.

"These results were confirmed in a second clinical population of older adults with airflow obstruction," he added.

The proteins identified in the study are predominantly liver-synthesized proteins that can have important anti-inflammatory activity through the inhibition of oxidative stress, which has been implicated in several diseases, including heart disease, Alzheimer's disease and Parkinson's disease.

To identify potential biomarkers, blood samples were collected from 43 subjects with a mean age of 48 years, including 21 with asthma, five with COPD and 17 healthy controls. Using proteomic techniques, plasma proteins were separated from all blood samples. Once protein biomarkers were identified and selected, the researchers measured the biomarkers' abilities, singly and in combination, to distinguish between the groups of patients.

To validate their results, the researchers conducted two additional assessments. In the first assessment, the original group was supplemented with an additional seven asthmatics and nine patients with COPD and repeated the biomarker assessment. The second assessment involved a separate population of 73 older subjects (over 55 years), including 14 with asthma, 22 with COPD, 14 with both conditions and 23 healthy controls. Results were confirmed in both validation groups.

Identifying biomarkers that are involved in the development of airway diseases may allow clinicians to diagnose the diseases in their earlier, and often more treatable, stages, Dr. Gibson noted.

"Our study identified a panel of highly discriminatory proteins that could be extremely useful in a clinical context," Dr. Gibson said. "Since these biomarkers are detectable in blood, which is readily obtainable from patients, and substances are currently available for testing the abundance of these proteins, this panel of biomarkers has the potential to become an extremely useful addition to the clinical diagnosis and management of respiratory disease."

Dr. Gibson noted proteomics played a vital role in the study, which was funded by the Australian government as part of its Cooperative Research Centre for Asthma and Airways program, and suggests the protein-based techniques may prove vital in future studies of biomarkers.

"Combined with well-defined clinical groups and advanced statistical analyses, we have shown that proteomics is a powerful tool for the identification of novel disease biomarkers," he said.

"The study is a good example of how high quality biological science can be translated effectively to a useful result for people with asthma and COPD. Future work is planned to study these markers in the lungs of patients with asthma and COPD, and apply the results in different clinical settings."


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. N. M. Verrills, J. A. Irwin, X. Y. He, L. G. Wood, H. Powell, J. L. Simpson, V. M. McDonald, A. Sim, P. G. Gibson. Identification of Novel Diagnostic Biomarkers for Asthma and Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine, 2011; DOI: 10.1164/rccm.201010-1623OC

Cite This Page:

American Thoracic Society. "Researchers link novel biomarkers to asthma and COPD." ScienceDaily. ScienceDaily, 21 March 2011. <www.sciencedaily.com/releases/2011/03/110311121830.htm>.
American Thoracic Society. (2011, March 21). Researchers link novel biomarkers to asthma and COPD. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2011/03/110311121830.htm
American Thoracic Society. "Researchers link novel biomarkers to asthma and COPD." ScienceDaily. www.sciencedaily.com/releases/2011/03/110311121830.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins