Featured Research

from universities, journals, and other organizations

Quest for cures for HIV

Date:
March 16, 2011
Source:
Women & Infants Hospital
Summary:
A new article explores the clinical characteristics that are important for researchers to consider when they study the female genital tract in the quest for cures for HIV.

A research article co-authored by Brenna Anderson, MD, director of Reproductive Infectious Diseases Consultation in the Division of Maternal-Fetal Medicine at Women & Infants Hospital of Rhode Island, was included in the recently published special issue of the American Journal of Reproductive Immunology.

Related Articles


The publication is an outgrowth of a workshop on the human immunodeficiency virus (HIV) that took place at Dartmouth Medical School in the summer of 2010. The workshop, sponsored by the National Institutes of Health and National Institute of Allergy and Infectious Diseases for invited attendees only, was designed to bring together HIV researchers who specialize in mucosal immunity. Mucosal immunity is one of the body's way of protecting itself against disease and is the next frontier for HIV researchers.

Dr. Anderson's article -- co-written with Susan Cu-Uvin, MD, of The Miriam Hospital -- is entitled "Clinical Parameters Essential to Methodology and Interpretation of Mucosal Responses." It explores the clinical characteristics that are important for researchers to consider when they study the female genital tract in the quest for cures for HIV.

With more than 30 million people diagnosed with HIV across the world, millions of dollars continue to be spent on research aimed at fighting the disease. While the advent of antiretroviral therapy to treat HIV has not slowed the spread of infection, research has helped health care providers understand the disease, which has changed the life expectancy of an individual diagnosed with HIV in the United States from terminal to chronic illness.

Over the past few years, research attention has shifted from blood to the genital tract as the major point-of-entry for the virus. To effectively produce results, however, the proper guidelines must be established for research into the genital tract's mucosal immunity, Dr. Anderson noted.

"The normal values for the measurement of immune globulins, for example, vary by approximately 100-fold based on the site and method of collection within the human female genital tract," explained Dr. Anderson, who is also assistant professor of obstetrics and gynecology at The Warren Alpert Medical School of Brown University. "More efforts are needed to standardize both sampling methods and assays of female genital tract immunity."

"Research attention has shifted from management of HIV to a focus on the most common site of acquisition -- the female genital tract," she explained. "If researchers do not consider specific clinical parameters when enrolling subjects into their studies, it could lead to faulty interpretation of results."

Important topics for researchers to consider, the article notes, are the method and source of sample collection, the individual patient characteristics, and, when recruiting HIV-infected women, HIV disease characteristics.

There are a number of clinical characteristics that are known to alter genital immunity, Dr. Anderson said. These include a woman's menstrual cycle, age, race, body mass index, any contraception being used, and recent intercourse.

"Contraception containing progesterone, for example, alter the cervical mucous and the uterine lining. Given that sex hormones alter many components of genital immunity, it is likely that hormonal contraception has some impact on the innate immunity within the female genital tract," she said. "This should be considered when conducting research."


Story Source:

The above story is based on materials provided by Women & Infants Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Brenna L. Anderson, Susan Cu-Uvin. Clinical Parameters Essential to Methodology and Interpretation of Mucosal Responses. American Journal of Reproductive Immunology, 2011; 65 (3): 352 DOI: 10.1111/j.1600-0897.2010.00947.x

Cite This Page:

Women & Infants Hospital. "Quest for cures for HIV." ScienceDaily. ScienceDaily, 16 March 2011. <www.sciencedaily.com/releases/2011/03/110316104125.htm>.
Women & Infants Hospital. (2011, March 16). Quest for cures for HIV. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2011/03/110316104125.htm
Women & Infants Hospital. "Quest for cures for HIV." ScienceDaily. www.sciencedaily.com/releases/2011/03/110316104125.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins