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New treatment may desensitize kids with milk allergies, study suggests

Date:
March 22, 2011
Source:
Stanford University Medical Center
Summary:
Milk allergy is the most common, affecting 2.5 percent of children under age 3. In a small clinical study, scientists report effectively desensitizing milk-allergic patients by increasing their exposure to milk in tandem with an allergy drug called omalizumab, allowing children to build up resistance quickly with limited allergic reactions.

Some 3 million children in the United States have some form of food allergy, ranging in severity from mild to life-threatening. Milk allergy is the most common, affecting 2.5 percent of children under age 3. In a small clinical study, immunologists and allergists at Children's Hospital Boston and the Stanford University School of Medicine report effectively desensitizing milk-allergic patients by increasing their exposure to milk in tandem with an allergy drug called omalizumab, allowing children to build up resistance quickly with limited allergic reactions.

Their new treatment regimen will be described on March 21 in one of eight "Late-Breaking Presentations" at the annual meeting of the American Academy of Allergy, Asthma and Immunology in San Francisco. The researchers, Lynda Schneider, MD, and Dale Umetsu, MD, PhD, at Children's Hospital Boston and Kari Nadeau, MD, PhD, at Stanford University and Lucile Packard Children's Hospital, showed that the majority of the milk-allergic subjects who completed the regimen passed a double-blind food challenge and were then able to ingest the equivalent of 8 ounces of milk or more per day.

Although food allergy is a major public health problem, currently there is no effective and safe treatment except to avoid the foods that can trigger an anaphylactic reaction, and to promptly treat reactions when they occur. But the need for new options is critical now as the number of children diagnosed with food allergies rises.

While previous studies showed that oral milk desensitization can increase the amount of milk tolerated by many of the treated subjects, Schneider, Umetsu and Nadeau launched a trial in 2009 aimed at carrying out the desensitization regimen in a shorter period of time with much fewer allergic reactions by including omalizumab, which binds up IgE, the family of antibodies that drive allergic responses. Omalizumab is marketed by the company Genentech under the brand name Xolair.

"This is the first study to use omalizumab in combination with oral desensitization," said Umetsu, who is also the Prince Turki bin Abdul Aziz al-Saud Professor of Pediatrics at Harvard Medical School. "Using omalizumab allowed us to escalate their milk intake very rapidly compared to other desensitization protocols, and still limit allergic reactions."

After first pretreating the children with omalizumab, the investigators then introduced milk in ever-increasing amounts over the next seven to 10 weeks, a relatively rapid desensitization period.

"This anti-IgE molecule is like a 'protective blanket,'" said Nadeau, an allergist and assistant professor of pediatrics at Stanford. "We think it possibly protects subjects from having reactions to food allergens during oral immunotherapy. For the first 16 weeks of oral desensitization, we gave omalizumab to try to decrease the severity and rate of allergic reactions when subjects consumed cow's milk. Without this treatment, 10 to 20 percent of people who start oral immunotherapy drop out, in part due to intolerable allergic reactions early in the treatment."

At the end of the desensitization period, the investigators stopped giving the children omalizumab, but continued to give them daily doses of milk (2,000 mg, or about 2 ounces) for eight additional weeks.

Nine of the 11 children then successfully completed an oral milk challenge. The next day, these nine children began to consume 8 to 12 ounces of dairy per day to maintain their tolerance with minimal or no adverse effects.

"We decided to start with milk because treating it successfully could change a child's lifestyle for the better," Umetsu noted. "These children had significant milk allergy, and were unlikely to outgrow it without some type of treatment. While we recognize that larger trials are necessary, these results are very promising, and suggest that a rapid and safe method of food desensitization might be available for patients in the near future."

"When you try to go on a diet that is completely free of milk, it is very difficult because many foods have a little bit of milk protein in them," Nadeau added. "From a practical standpoint, this treatment allowed these patients to increase all types of milk products in their diets: they were able to eat yogurt, cheese, bread, a muffin … one patient in our study said, 'I can finally eat goldfish crackers.' Another patient, for the first time in her life, was able to have M&Ms."

Based on the results of this study, Schneider and Umetsu are launching a new trial focused on peanut allergy (http://clinicaltrials.gov/ct2/show/NCT01290913).

The study was supported by the Translational Research Program at Children's Hospital Boston; Harvard Catalyst | The Harvard Clinical and Translational Science Center; Spectrum, the Stanford Center for Clinical and Translational Research and Education; the Bunning Food Allergy Project; the Food Allergy Initiative; Genentech; the Stanford Institute for Immunity, Transplantation, and Infection; and the Fund for Food Allergy Research at Stanford.


Story Source:

The above story is based on materials provided by Stanford University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Stanford University Medical Center. "New treatment may desensitize kids with milk allergies, study suggests." ScienceDaily. ScienceDaily, 22 March 2011. <www.sciencedaily.com/releases/2011/03/110321183038.htm>.
Stanford University Medical Center. (2011, March 22). New treatment may desensitize kids with milk allergies, study suggests. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2011/03/110321183038.htm
Stanford University Medical Center. "New treatment may desensitize kids with milk allergies, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/03/110321183038.htm (accessed October 2, 2014).

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