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Research practices must be changed to minimize fraud, deception, physicians argue

Date:
March 22, 2011
Source:
University of Michigan Health System
Summary:
In a new commentary, two physicians call for changes throughout the research process to adjust expectations for researchers that conduct studies, the journals that publish results and the public that responds to the findings.

In 1998, a study linking the measles, mumps and rubella (MMR) vaccine to autism in children appeared in a respected medical journal. For a decade, the study grabbed headlines worldwide. Worried parents rejected the life-saving vaccine for their children and those with autistic children agonized that they allowed an injection that caused the condition.

But the vaccine-autism research was a fraud. The paper was retracted 12 years later, denounced as an elaborate deception.

"The fraud in that MMR study epitomizes how fabricated research can lead to a domino effect of tragic consequences," says Vineet Chopra, M.D., F.A.C.P., F.H.M., assistant professor of Internal Medicine at U-M. "Patients fear potentially lifesaving interventions, clinicians alter practice and scientists and governments waste precious resources to evaluate researchers' claims."

Chopra expresses these concerns in a commentary published in the Journal of the American Medical Association March 23 with Matthew Davis, M.D., M.A.P.P., associate professor of pediatrics and communicable diseases, internal medicine and public policy at the University of Michigan Medical School and Gerald R. Ford School of Public Policy. They call for changes throughout the research process to adjust expectations for researchers that conduct studies, the journals that publish results and the public that responds to the findings.

Chopra and Davis emphasize the critical importance of equipoise -- a state of genuine uncertainty on the part of the researcher as to what a study will reveal.

"In an era of increasing competition for funding and publication, researchers face mounting pressure to report the results they wish to see," says Davis. "Of course, it's natural for the public to want unequivocal advances in understanding and the latest accomplishments in medical research. But research doesn't always yield those results.

"The key is for funders, journals, the media and the public to value equipoise in the research process, rather than only the results."

In their JAMA commentary, Chopra and Davis recommend steps to reach research equipoise:

  1. Mandate the public release of all available data in connection with a study, as opposed to specific data associated with outcomes.
  2. Reduce publication bias, in which medical journals accept and publish chiefly those studies with statistically significant results. This jeopardizes consideration and dissemination of research pertaining to findings on both sides of an issue, and influences investigators before research begins.
  3. Shift the focus of public and private sponsors of research from outcome to process, affirming that study veracity is more valuable than results.
  4. Train researchers to recognize, appreciate and root out biases in their work.

"Researchers may lie about their research for personal or political gain. They make front page news when they get caught, but they represent a small part of the overall picture. A broader problem occurs when a researcher conducts a study with an answer to their question already in mind. Their certainty, rather than genuine uncertainty, influences their investigation and reporting, leading to results that may not be accurate," says Chopra.


Story Source:

The above story is based on materials provided by University of Michigan Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. V. Chopra, M. Davis. In Search of Equipoise. JAMA: The Journal of the American Medical Association, 2011; 305 (12): 1234 DOI: 10.1001/jama.2011.363

Cite This Page:

University of Michigan Health System. "Research practices must be changed to minimize fraud, deception, physicians argue." ScienceDaily. ScienceDaily, 22 March 2011. <www.sciencedaily.com/releases/2011/03/110322161526.htm>.
University of Michigan Health System. (2011, March 22). Research practices must be changed to minimize fraud, deception, physicians argue. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/03/110322161526.htm
University of Michigan Health System. "Research practices must be changed to minimize fraud, deception, physicians argue." ScienceDaily. www.sciencedaily.com/releases/2011/03/110322161526.htm (accessed July 31, 2014).

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