Featured Research

from universities, journals, and other organizations

Keeping cancer dormant: Researchers target tumor metabolism by blocking energy production required for malignant cancer growth

Date:
March 30, 2011
Source:
Society of Interventional Radiology
Summary:
The growth and spread of breast cancer tumors may be delayed with a promising treatment that combines innovative strategies: blocking the enzyme needed to "energize" cancer cells and infusing a potent drug directly into the tumor, with minimum exposure to healthy tissues, according to researchers.

The growth and spread of breast cancer tumors may be delayed with a promising treatment that combines two innovative strategies: blocking the enzyme needed to "energize" cancer cells and infusing a potent drug directly into the tumor, with minimum exposure to healthy tissues, according to researchers presenting at the Society of Interventional Radiology's 36th Annual Scientific Meeting in Chicago, Ill.

"Once breast cancer metastases have been detected, current treatments (such as surgical resection or tumor removal) may be ineffective. We've found a way to keep a breast cancer tumor dormant -- thus potentially increasing the likelihood that a tumor can be treated successfully," noted Jeff H. Geschwind, M.D., FSIR, professor of radiology, surgery and oncology and director of vascular and interventional radiology at Johns Hopkins University School of Medicine in Baltimore, Md. "Our study shows that an ultrasound-guided intra-tumoral treatment with a drug called 3-bromopyruvate (3-BrPA) may be a very promising new therapy for patients with breast cancer that delays tumor growth and spread," added Geschwind, who is also the director of the Interventional Radiology Center at Johns Hopkins University School of Medicine.

"Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death in women in the United States," said Geschwind. It was estimated that 207,090 women would be diagnosed with -- and 39,840 women would die of -- cancer of the breast in 2010 -- thus affecting one in eight women during their lives. "The development of new treatment options for this lethal disease is imperative," said Geschwind, indicating that once metastasis is detected, a patient may have (on average) only 18 to 24 months to live.

Increased awareness and screening has increased the likelihood of diagnosing early-stage cancer tumors, and breast cancer is treated in several ways, depending on the kind of breast cancer and how far it has spread, said Geschwind. "However, a significant number of patients experience treatment failure, developing local tumor recurrence or metastatic disease after an initial response to treatments (like chemotherapy and radiation)," he explained. "Metastatic spread may occur in 50 percent of cases with apparently localized breast cancer, and nearly 30 percent of patients with lymph node-negative disease will develop distant metastases within five years -- underlining the importance of the development of novel, targeted, minimally invasive treatment strategies for tumor control and prevention," he added.

In animal studies, the research team has shown how interventional radiologists are uniquely positioned to combine their basic science knowledge -- in this case resulting in the exploitation of tumor metabolism as a target for breast cancer therapy -- with their vast experience in minimally invasive treatment strategies. "Breast tumor cells depend on a metabolic pathway called glycolysis to generate the energy required for their malignant growth. By inhibiting a specific enzyme with the anti-glycolytic agent 3-BrPA, the energy production required for tumor cell growth and spread is blocked," said Geschwind. "Disrupt glycolysis and cancer cells are unable to produce enough energy to survive," he said.

The researchers were then able to maximize the amount of drug delivered to a tumor by infusing the potent drug directly into the tumor -- using imaging to guide them -- and minimizing exposure of healthy tissue to the therapy, explained Geschwind. "The biological targeting abilities of anti-glycolytic treatment combined with an image-guided minimally invasive delivery strategy is a promising approach to reducing the growth and spread of breast cancer in patients," he emphasized.

"In our study, a statistically significant difference in tumor volume was observed. Our results support the continuing development of this highly innovative interventional radiology approach for the safe and effective treatment of breast cancer," he added. "Before we can test our novel treatment strategy in individuals with breast cancer, it is important to perform additional animal studies of a larger size to confirm the efficacy of the treatment and to verify that there are no toxic effects on the normal tissues," noted Geschwind.


Story Source:

The above story is based on materials provided by Society of Interventional Radiology. Note: Materials may be edited for content and length.


Cite This Page:

Society of Interventional Radiology. "Keeping cancer dormant: Researchers target tumor metabolism by blocking energy production required for malignant cancer growth." ScienceDaily. ScienceDaily, 30 March 2011. <www.sciencedaily.com/releases/2011/03/110329095436.htm>.
Society of Interventional Radiology. (2011, March 30). Keeping cancer dormant: Researchers target tumor metabolism by blocking energy production required for malignant cancer growth. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2011/03/110329095436.htm
Society of Interventional Radiology. "Keeping cancer dormant: Researchers target tumor metabolism by blocking energy production required for malignant cancer growth." ScienceDaily. www.sciencedaily.com/releases/2011/03/110329095436.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins