Featured Research

from universities, journals, and other organizations

BRCA2 mutations associated with improved survival for ovarian cancer

Date:
June 27, 2011
Source:
American Association for Cancer Research
Summary:
Women with ovarian cancer who have the BRCA2 gene mutation are more likely to survive the malignancy than women with the BRCA1 mutation, or women without either mutation, according to new research.

Women with ovarian cancer who have the BRCA2 gene mutation are more likely to survive the malignancy than women with the BRCA1 mutation, or women without either mutation.

In results presented at the AACR 102nd Annual Meeting 2011, held April 2-6, Kelly Bolton, a fellow at the National Cancer Institute, said the findings describe the effect of these mutations in ovarian cancer survival.

"There was some previous evidence that women with ovarian cancer who have mutations in the BRCA genes show improved survival compared to non-mutation carriers," said Bolton. "Our study clearly shows that this survival difference is real. We also provide the first solid evidence that BRCA1 and BRCA2 mutations don't have the same impact on ovarian cancer survival."

"Previous studies have been somewhat conflicting because of their small size and methodological limitations," she added.

Bolton and colleagues evaluated 3,531 cases of epithelial ovarian cancer, including 1,178 women with BRCA1 mutations, 367 with BRCA2 mutations, and 1,986 with neither mutation. Overall, women with either the BRCA1 or BRCA2 mutation had better survival compared to patients who carried the wild-type for both genes. After adjusting for baseline characteristics, the five-year survival of women without mutations was 36 percent. Survival for BRCA1 or BRCA2 mutation carriers was 46 percent and 61 percent, respectively.

Bolton said further study is needed to explain why women with BRCA2 mutations had better survival than BRCA1 carriers, or those without either mutation. She hypothesized the mutations may affect a patient's response to chemotherapy.

Approximately 1 in 400 to 1 in 800 women are born with mutations in either BRCA1 or BRCA2, which are known to predispose carriers to the development of ovarian and breast cancer. The risks differ between the two mutations. Roughly 5 percent of ovarian cancer patients carry mutations in BRCA1 or BRCA2.

"This information may lead to improvements in clinical management of patients with these mutations," she suggested.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "BRCA2 mutations associated with improved survival for ovarian cancer." ScienceDaily. ScienceDaily, 27 June 2011. <www.sciencedaily.com/releases/2011/04/110404111040.htm>.
American Association for Cancer Research. (2011, June 27). BRCA2 mutations associated with improved survival for ovarian cancer. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2011/04/110404111040.htm
American Association for Cancer Research. "BRCA2 mutations associated with improved survival for ovarian cancer." ScienceDaily. www.sciencedaily.com/releases/2011/04/110404111040.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com
How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
How Detroit's Money Woes Led To U.N.-Condemned Water Cutoffs

How Detroit's Money Woes Led To U.N.-Condemned Water Cutoffs

Newsy (Oct. 20, 2014) The United Nations says water is a human right, but should it be free? Detroit has cut off water to residents who can't pay, and the U.N. isn't happy. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins