Featured Research

from universities, journals, and other organizations

Dangerous blood pressure increases during exercise can be blocked, researchers find

Date:
April 4, 2011
Source:
UT Southwestern Medical Center
Summary:
Researchers have identified one reason people with hypertension experience an even greater increase in their blood pressure when they exercise, and they've learned how to prevent the rise.

UT Southwestern Medical Center researchers have identified one reason people with hypertension experience an even greater increase in their blood pressure when they exercise, and they've learned how to prevent the rise.

A study in a March issue of the Journal of Physiology reported that hypertensive people who exercise undergo decreased blood flow and oxygen in muscles. The scientists also identified a specific type of blood pressure medication that minimizes this effect.

"While there are many hypertension medications effective at lowering blood pressure at rest, very few are effective during exercise," said Dr. Wanpen Vongpatanasin, associate professor of internal medicine at UT Southwestern and lead author of the study. "People with high blood pressure need to exercise not only to help their blood pressure, but also their overall cardiovascular health."

Dr. Vongpatanasin said that some people with high blood pressure stop exercising out of fear of heart attack or stroke, and that sometimes physicians counsel those patients to limit activity because of those concerns.

While it's been known that blood pressure increases during exercise in people with hypertension, a mechanism behind the action and a way to block it in humans hadn't been identified previously.

Dr. Vongpatanasin and colleagues had 13 participants with mild hypertension and 13 with normal blood pressure perform hand grip exercises under regular conditions, followed by activity under conditions that affect a part of the nervous system that controls blood pressure.

They found increased nerve activity in hypertensive participants during exercise but not in those with normal blood pressure. Blood flow and oxygen levels in the arm muscles also fell more rapidly in the hypertensive group.

"In normal people, the body can increase blood flow to the working muscle despite increase in nerve activity, which tends to cause blood vessels to constrict," Dr. Vongpatanasin said. "Hypertensive patients have increased nerves and impaired ability to maintain muscle blood flow adequately."

Researchers then treated study participants with two types of blood pressure medications. An angiotensin receptor blocker, which prevents the hormone angiotensin from increasing blood pressure, increased blood flow during exercise. A diuretic that reduces blood pressure by stimulating sodium loss did not.

"Since nerve increases weren't reduced during treatment, we believe the angiotensin receptor blocker works directly on blood vessels to improve blood flow," Dr. Vongpatanasin said.

The next step, she said, will be to see if other hormones associated with angiotensin are involved in similar responses.

Other UT Southwestern researchers involved in the study were Zhongyun Wang, research associate in internal medicine; Debbie Arbique, advanced practice nurse in internal medicine; Dr. Gary Arbique, associate professor of radiology; Beverley Adams Huet, assistant professor of clinical sciences; and Dr. Jere Mitchell, clinical professor of internal medicine and physiology. Researchers from Cedars-Sinai Medical Center also participated.

The study was funded by the National Institutes of Health, the National Institute of Diabetes and Digestive and Kidney Diseases' George M. O'Brien Kidney Research Core Center at UT Southwestern and a Clinical and Translational Sciences Award from the National Center for Research Resources.


Story Source:

The above story is based on materials provided by UT Southwestern Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. W. Vongpatanasin, Z. Wang, D. Arbique, G. Arbique, B. Adams-Huet, J. H. Mitchell, R. G. Victor, G. D. Thomas. Functional sympatholysis is impaired in hypertensive humans. The Journal of Physiology, 2011; 589 (5): 1209 DOI: 10.1113/jphysiol.2010.203026

Cite This Page:

UT Southwestern Medical Center. "Dangerous blood pressure increases during exercise can be blocked, researchers find." ScienceDaily. ScienceDaily, 4 April 2011. <www.sciencedaily.com/releases/2011/04/110404173250.htm>.
UT Southwestern Medical Center. (2011, April 4). Dangerous blood pressure increases during exercise can be blocked, researchers find. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2011/04/110404173250.htm
UT Southwestern Medical Center. "Dangerous blood pressure increases during exercise can be blocked, researchers find." ScienceDaily. www.sciencedaily.com/releases/2011/04/110404173250.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins