Featured Research

from universities, journals, and other organizations

Protein found to be the link missing between HPV infection and cervical cancer development

Date:
April 5, 2011
Source:
Georgetown University Medical Center
Summary:
Most women are infected with human papillomavirus (HPV), which can cause cervical cancer -- yet few develop the cancer. Now researchers believe they have found the missing link explaining why: activation of the beta-catenin oncogene.

Most women are infected with human papillomavirus (HPV), which can cause cervical cancer -- yet few develop the cancer. Now researchers at Georgetown Lombardi Comprehensive Cancer Center, a part of Georgetown University Medical Center, believe they have found the missing link explaining why: activation of the beta-catenin oncogene.

At the American Association for Cancer Research (AACR) 102nd Annual Meeting 2011, the researchers say that a new mouse model they developed demonstrates that switching the oncogene on in the cervix of HPV infected mice promoted development of aggressive cervical cancer.

These early findings suggest clinical implications that are both preventive and therapeutic, says the study's senior investigator, Aykut Üren, M.D., an associate professor of oncology at Lombardi

"We can potentially develop a screening method to check for HPV and beta-catenin activation in pap smears," he says. "That will identify individuals at a higher risk of developing cancer compared to ones who are only HPV positive. Then they can be more closely followed for cancer development."

Secondly, Üren points out that there are new drugs being developed to target the Wnt pathway that includes the beta-catenin protein. "Activation of this pathway is very common in colon cancer and is found in a dozen other cancers, so these same novel drugs might be useful in treating advanced stage cervical cancer patients," he says.

Üren points out that while cervical cancer has been kept in check in the U.S. and other developed nations due to use of Pap smears and, of late, the HPV vaccine that protects uninfected females, cervical cancer is the second leading cause of cancer deaths in women worldwide. "New international approaches to control and treat cervical cancer are desperately needed," he says.

Their novel mouse model was created by cross-breeding two other strains of transgenic mice -- one that expresses HPV genes in the cervix and the other that forces the beta catenin/Wnt pathway to be constantly activated, also in the cervix. While the HPV infected mice are programmed to develop cervical cancer, the tumors that grew in the double transgenic mice were larger and more aggressive.

The study was funded by the National Cancer Institute. Gülay Bulut, Ph.D., a postdoctoral researcher in Üren's laboratory, will present the results at a poster session.

The authors report having no personal financial interests related to the study.


Story Source:

The above story is based on materials provided by Georgetown University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Georgetown University Medical Center. "Protein found to be the link missing between HPV infection and cervical cancer development." ScienceDaily. ScienceDaily, 5 April 2011. <www.sciencedaily.com/releases/2011/04/110405141701.htm>.
Georgetown University Medical Center. (2011, April 5). Protein found to be the link missing between HPV infection and cervical cancer development. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2011/04/110405141701.htm
Georgetown University Medical Center. "Protein found to be the link missing between HPV infection and cervical cancer development." ScienceDaily. www.sciencedaily.com/releases/2011/04/110405141701.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) — The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) — A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) — The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) — Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins