Featured Research

from universities, journals, and other organizations

New device promises safer way to deliver powerful drugs

Date:
April 7, 2011
Source:
American Institute of Physics
Summary:
A new drug delivery device promises to unlock the potential of photosensitive chemicals to kill drug-resistant infections and perhaps cancer tumors as well.

A new drug delivery device designed and constructed by Jie Chen, Thomas Cesario and Peter Rentzepis promises to unlock the potential of photosensitive chemicals to kill drug-resistant infections and perhaps cancer tumors as well.

Related Articles


Photosensitive chemicals are molecules that release single oxygen atoms and chemical radicals when illuminated. These radicals are very active chemically, and can rip apart and destroy bacteria, said Peter Rentzepis, a professor of chemistry at University of California, Irvine.

Yet photosensitive chemicals are not approved for use in the United States, and used relatively rarely in Europe. This is because they are highly toxic and difficult to activate beneath the skin, since light only penetrates a few millimeters into the body.

Photosensitive chemicals also cause severe reactions, including headaches, nausea, and light sensitivity for 30 days. They kill healthy cells as well as bacteria. Although several have therapeutic potential, they are too toxic for human use by injection.

The researchers solved this problem with an optical fiber-based device that can deliver very small amounts of photosensitive chemicals to internal organs with pinpoint accuracy.

The device consists of three components. The first is an imaging component similar to the charge coupled devices (CCDs) in digital cameras. It enables a physician to guide the device to the infection.

A 1-millimeter-diameter flexible optical fiber attached micro sized high-power LED or laser diode provides the light for the CCD. Once the physician positions the device, the same light source shines with greater intensity to activate the medicine.

The third component is a hollow tube connected to a syringe of medicine to deliver the medicine to the infection. Rentzepis adds glycol, a thickening agent used in surgical soaps, to keep the medicine from spreading to healthy cells.

Pulling the syringe backwards creates a vacuum that sucks up any remaining chemical after the procedure.

"We can insert the instrument through the nose, bowels, mouth, or almost any opening and direct it where we want," Rentzepis said. "It lets us deliver very small amounts of these chemicals right to an infection or tumor, then remove them before they damage healthy cells."

The researchers plan to test the device on animals with infections and cancer.


Story Source:

The above story is based on materials provided by American Institute of Physics. Note: Materials may be edited for content and length.


Cite This Page:

American Institute of Physics. "New device promises safer way to deliver powerful drugs." ScienceDaily. ScienceDaily, 7 April 2011. <www.sciencedaily.com/releases/2011/04/110406123400.htm>.
American Institute of Physics. (2011, April 7). New device promises safer way to deliver powerful drugs. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/2011/04/110406123400.htm
American Institute of Physics. "New device promises safer way to deliver powerful drugs." ScienceDaily. www.sciencedaily.com/releases/2011/04/110406123400.htm (accessed November 22, 2014).

Share This


More From ScienceDaily



More Matter & Energy News

Saturday, November 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Toyota's Hydrogen Fuel-Cell Green Car Soon Available in the US

Toyota's Hydrogen Fuel-Cell Green Car Soon Available in the US

AFP (Nov. 21, 2014) Toyota presented its hydrogen fuel-cell compact car called "Mirai" to US consumers at the Los Angeles auto show. The car should go on sale in 2015 for around $60.000. It combines stored hydrogen with oxygen to generate its own power. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Google Announces Improvements To Balloon-Borne Wi-Fi Project

Google Announces Improvements To Balloon-Borne Wi-Fi Project

Newsy (Nov. 21, 2014) In a blog post, Google said its balloons have traveled 3 million kilometers since the start of Project Loon. Video provided by Newsy
Powered by NewsLook.com
NSA Director: China Can Damage US Power Grid

NSA Director: China Can Damage US Power Grid

AP (Nov. 20, 2014) China and "one or two" other countries are capable of mounting cyberattacks that would shut down the electric grid and other critical systems in parts of the United States, according to Adm. Michael Rogers, director of the National Security Agency and hea Video provided by AP
Powered by NewsLook.com
Latest Minivan Crash Tests Aren't Pretty

Latest Minivan Crash Tests Aren't Pretty

Newsy (Nov. 20, 2014) Five minivans were put to the test in head-on crash simulations by the Insurance Institute for Highway Safety. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins