Featured Research

from universities, journals, and other organizations

Corticosteroid use during pregnancy not linked to facial clefts in infants, study finds

Date:
April 11, 2011
Source:
Canadian Medical Association Journal
Summary:
The use of corticosteroids during pregnancy does not appear to be associated with an increased risk of orofacial clefts in infants, according to a new study.

The use of corticosteroids during pregnancy does not appear to be associated with an increased risk of orofacial clefts in infants, according to an article in CMAJ (Canadian Medical Association Journal).

Many previous studies have shown associated risks with use of oral corticosteroids, although they were small studies.

Corticosteroids are used for asthma, allergies, eczema and psoriasis, autoimmune diseases and cancer. Use of corticosteroids during pregnancy has been associated with orofacial clefts in animals and similar risks in humans are suspected.

This study, by researchers based in Copenhagen, Denmark, looked at data on 832 636 live births over the study period from January 1996 to September 2008. They used data from the Danish Medical Birth Registry, the Danish Prescription Drug Register and the National Hospital Discharge Register.

In the study group, 163 494 women (19.6%) used corticosteroids once or more in the four weeks before pregnancy up to birth. The most common were dermatological corticosteroids (43.3%), other topical solutions (e.g. eye drops or ear drops), nasal sprays (21.6%), inhalants, (14.3%) and oral medications (4.2%). First trimester use occurred in 51 973 (6.2%) of women. The researchers identified 1232 orofacial clefts in infants up to age 1 year.

"Women who used any corticosteroid during the first trimester were not significantly more likely to bear offspring with a cleft lip with or without a cleft palate or a cleft palate alone than women who did not use any corticosteroid during the first trimester," write Dr. Anders Hviid and Ditte Mψlgaard-Nielsen, Statens Serum Institute, Copenhagen, Denmark.

"However, the use of dermatologic corticosteroids was associated with an increased risk of cleft lip with or without cleft palate," the authors state, although oral, inhalants, nasals or other topical corticosteroids were not. They suggest this association may be from multiple statistical comparisons rather than causality.

They conclude, "our results add to the safety information for a class of drugs commonly used during pregnancy." They caution that the apparent lack of an association in this study supports that moderate to strong risks are unlikely, but not that corticosteroids are completely safe.


Story Source:

The above story is based on materials provided by Canadian Medical Association Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Anders Hviid, Ditte Mψlgaard-Nielsen. Corticosteroid use during pregnancy and risk of orofacial clefts. CMAJ, 2011; DOI: 10.1503/cmaj.101063

Cite This Page:

Canadian Medical Association Journal. "Corticosteroid use during pregnancy not linked to facial clefts in infants, study finds." ScienceDaily. ScienceDaily, 11 April 2011. <www.sciencedaily.com/releases/2011/04/110411121526.htm>.
Canadian Medical Association Journal. (2011, April 11). Corticosteroid use during pregnancy not linked to facial clefts in infants, study finds. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2011/04/110411121526.htm
Canadian Medical Association Journal. "Corticosteroid use during pregnancy not linked to facial clefts in infants, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/04/110411121526.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) — A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) — Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) — The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) — A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins