Featured Research

from universities, journals, and other organizations

Treatment found for rare lung disease, study suggests

Date:
April 13, 2011
Source:
Oregon Health & Science University
Summary:
A new study has revealed a drug approved to prevent rejection in organ transplant patients helped treat a rare lung disease in women.

An Oregon Health & Science University researcher has co-authored an international study that revealed a drug approved to prevent rejection in organ transplant patients helped treat a rare lung disease in women. The life-threatening disease has no cure and, until now, no known treatment.

Related Articles


The clinical trial of the drug -- called sirolimus -- was the first randomized, controlled study designed to develop a therapy for the lung disease, lymphangioleiomyomatosis, or LAM.

LAM is a progressive, cystic lung disease that occurs almost exclusively in women. In LAM, smooth muscle cells grow uncontrollably and spread to restricted areas in the body, including the lungs, lymph nodes and vessels and kidneys, limiting the flow of air, blood and immune system fluid, or lymph.

Shortness of breath and recurrent lung collapse are common in patients with LAM; until now, lung transplantation has been the only hope for patients who progress to respiratory failure. LAM affects about five per million people.

The positive results from the clinical trial of sirolimus, also known as rapamycin, were reported last month in the online edition of the New England Journal of Medicine.

The lead investigators in the study were from the University of Cincinnati and Cincinnati Children's Hospital Medical Center. Alan Barker, M.D., an OHSU expert in rare lung diseases, was a principal investigator in the study.

The study was conducted at 13 institutions throughout the United States, Canada and Japan. The only West Coast institutions involved in the study were OHSU and the University of California at Los Angeles. Research subjects from the Northwest and northern California were enrolled in the study at OHSU.

Eighty-nine women with LAM, aged 18 or older, participated in the study. Some were treated with sirolimus; others were given a placebo.

The researchers found that sirolimus stabilized lung function and was associated with improvement in measures of functional performance and quality of life.

OHSU's Barker said that the study results point to a potential treatment for LAM. The results are also important because they could serve as a model for treating common types of cancers.

"Like cancer, LAM occurs when cells grow out of control; in LAM's case, cells in the blood vessels and breathing passages in the lung grow out of control," Barker said. "This drug stopped that abnormal growth of cells."

Barker said that OHSU also will be part of a follow-up study that examines the effectiveness of another drug in treating LAM.

The sirolimus study was funded by the National Institutes of Health's Office of Rare Disease Research; the Food and Drug Administration; the LAM Foundation; the Japanese Ministry of Health, Labour and Welfare; the Canadian Institutes of Health Research; Cincinnati Children's Hospital, the University of Cincinnati; the Tuberous Sclerosis Alliance Rothberg Courage Award; and Vi and John Adler and the Adler Foundation.

Pfizer, maker of sirolimus, provided the drug and financial support but had no role in study design, conduct, analysis or reporting.


Story Source:

The above story is based on materials provided by Oregon Health & Science University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Francis X. McCormack, Yoshikazu Inoue, Joel Moss, Lianne G. Singer, Charlie Strange, Koh Nakata, Alan F. Barker, Jeffrey T. Chapman, Mark L. Brantly, James M. Stocks, Kevin K. Brown, Joseph P. Lynch, Hilary J. Goldberg, Lisa R. Young, Brent W. Kinder, Gregory P. Downey, Eugene J. Sullivan, Thomas V. Colby, Roy T. McKay, Marsha M. Cohen, Leslie Korbee, Angelo M. Taveira-DaSilva, Hye-Seung Lee, Jeffrey P. Krischer, Bruce C. Trapnell. Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis. New England Journal of Medicine, 2011; 110316140320097 DOI: 10.1056/NEJMoa1100391

Cite This Page:

Oregon Health & Science University. "Treatment found for rare lung disease, study suggests." ScienceDaily. ScienceDaily, 13 April 2011. <www.sciencedaily.com/releases/2011/04/110411164009.htm>.
Oregon Health & Science University. (2011, April 13). Treatment found for rare lung disease, study suggests. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2011/04/110411164009.htm
Oregon Health & Science University. "Treatment found for rare lung disease, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/04/110411164009.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins