Featured Research

from universities, journals, and other organizations

Statins may protect against kidney complications following elective surgery, study suggests

Date:
April 11, 2011
Source:
American Society of Nephrology
Summary:
Taking a statin before having major elective surgery reduces potentially serious kidney complications, according to a new study.

Taking a statin before having major elective surgery reduces potentially serious kidney complications, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN).

Each year, more than 230 million major elective surgeries are performed around the world. Unfortunately, many patients who undergo major operations develop kidney injury soon after surgery, often due to decreased blood flow to the kidneys and/or the effects of inflammation.

Animal studies suggest that the cholesterol-lowering drugs called statins protect the kidneys from such damage, but whether a similar benefit occurs in humans is uncertain. To investigate, Amber Molnar, MD (University of Western Ontario and Lawson Health Research Institute, in London, Canada), Amit Garg, MD, PhD (University of Western Ontario and Lawson Health Research Institute, in London; and the Institute for Clinical Evaluative Sciences, in Toronto, Canada) and their colleagues conducted a population-based retrospective study of all older patients who underwent major elective surgery in the province of Ontario, Canada from 1995 to 2008. Surgeries included cardiac, thoracic, vascular, intra-abdominal, and retroperitoneal procedures.

A total of 213,347 patients from 211 hospitals underwent major elective surgery, and 4,020 patients (1.9%) developed postoperative kidney injury within two weeks of surgery. A total of 1,173 patients (0.5%) required dialysis within two weeks of surgery, and 5,974 patients (2.8%) died within a month of surgery.

Prior to surgery, 67,941 patients (32%) were taking a statin. Patients taking a statin were 20% less likely to develop kidney injury, need dialysis, and die compared to patients who were not taking a statin. Also, there was evidence of a dose-effect, with patients on higher potency statins having less kidney injury. In addition, statins were beneficial whether they were started greater than 90 days or less than 30 days prior to surgery.

"Our study suggests that statin use in older persons results in less kidney injury following major elective surgery and reduces the risk of premature death after surgery," said Dr. Molnar. She added that the results warrant further investigation with more rigorous studies, but such trials will be difficult to carry out. "Conducting randomized controlled trials to examine whether statins are protective against definitive renal outcomes, such as acute dialysis, will be logistically challenging given that the need for acute dialysis is a relatively rare event," she said.

Study co-authors include Steven Coca, MD, Chirag Parikh MD, PhD (Yale University School of Medicine); PJ Devereaux, MD, PhD, Michael Walsh, MD (McMaster University, in Hamilton, Canada); Arsh Jain, MD, Abhijat Kitchlu, Nausheen Siddiqui, MD (University of Western Ontario, London, Canada); Jin Luo (Institute for Clinical Evaluative Sciences, Toronto, Canada); J. Michael Paterson (Institute for Clinical Evaluative Sciences, in Toronto, McMaster University, in Hamilton, and the University of Toronto, Canada); and Ron Wald, MD (University of Toronto, Canada).


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal References:

  1. Amber Molnar and Amit Garg et al. Statin Use Associates with Lower Incidence of Acute Injury after Major Elective Surgery. Journal of the American Society Nephrology, April 14, 2011 DOI: 10.1681/ASN.2010050442
  2. Sushrut Waikar and Steven Brunelli. Statin Use Associates with Less Acute Kidney Injury after Major Elective Surgery. Journal of the American Society Nephrology, April 14, 2011 DOI: 10.1681/ASN.2011020186

Cite This Page:

American Society of Nephrology. "Statins may protect against kidney complications following elective surgery, study suggests." ScienceDaily. ScienceDaily, 11 April 2011. <www.sciencedaily.com/releases/2011/04/110411171845.htm>.
American Society of Nephrology. (2011, April 11). Statins may protect against kidney complications following elective surgery, study suggests. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2011/04/110411171845.htm
American Society of Nephrology. "Statins may protect against kidney complications following elective surgery, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/04/110411171845.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins