Featured Research

from universities, journals, and other organizations

New evidence that chronic ulcerative stomatitis is an autoimmune disease

Date:
April 14, 2011
Source:
Tufts University, Health Sciences
Summary:
In a study investigating the cause of a little-understood condition called chronic ulcerative stomatitis (CUS), researchers have provided evidence that an autoimmune response contributes to the painful oral disease, supporting the classification of CUS as an autoimmune disease.

In the first study investigating the origins of a little-known condition called chronic ulcerative stomatitis (CUS), researchers at Tufts University School of Dental Medicine provide evidence that an autoimmune response contributes to the painful oral sores that characterize the disease. The study findings support the classification of CUS as a new autoimmune disease.

Related Articles


Chronic ulcerative stomatitis is characterized by painful, recurring sores in the mouth. Thus far, it has been diagnosed most frequently in white women in their 40's and 50's and may appear similar to oral erosive lichen planus. Only 39 cases of CUS have been reported in the English-language medical literature since it was identified as a clinically distinct condition in 1989, but it is likely under-diagnosed because of low awareness among clinicians and the extensiveness of the testing that would confirm its presence.

"Currently, diagnosing CUS requires a surgical biopsy which then must be sent to an outside lab for special processing for immunofluorescence microscopic examination. Accurate diagnosis is important because the usual treatment option for immunologically-mediated diseases, corticosteroids, is often not effective in treating CUS," said senior author, Lynn Solomon, DDS, MS, associate professor in the department of oral and maxillofacial pathology at Tufts University School of Dental Medicine (TUSDM).

"In previous studies, we identified that CUS patients had specific autoantibodies -antibodies produced by an immune response to the body's own tissue -- but we weren't sure whether these autoantibodies were contributing to CUS or part of a benign biological process. In this study, we determined that autoantibodies fulfill the criteria of pathogenetic antibodies and do contribute to the disease," she continued.

In this in vitro study, the researchers applied antibodies from four CUS patients to Human Skin Equivalents (HSEs), a three-dimensional model of skin tissues. At low concentrations, the CUS antibodies appeared to have no effect. At higher concentrations, however, the researchers reported complete detachment of the surface layer of tissue, known as epithelium.

The researchers found that the CUS autoantibodies do not cause damage to the surface epithelial cells, but cause a change in the cell-binding proteins that allow the surface layer to attach to the connective tissue beneath them. This weakened cohesion results in breakdown of the tissue, which would result in the sores that characterize CUS.

"In our future research, we would like to gain a better understanding of the mechanisms linking the autoimmune response to ulcerative sores so that we can optimize approaches to managing the condition. Additional data will help us evaluate hydroxychloroquine therapy, an antimalarial drug used off-label that provides relief in many cases, but which is not well-tolerated by some patients and which may have serious side effects," said Solomon.

The first author on the paper, Mark Carlson, PhD, now at Organogenesis, Inc., is an alumnus of the Training in Education and Critical Research Skills (TEACRS) program at Tufts, where he was a fellow in Jonathan Garlick's lab at TUSDM. TEACRS, funded by the National Institute of General Biomedical Sciences, part of the National Institutes of Health, is a program that fosters academic biomedical research and education leaders.

An additional author is Jonathan Garlick, DDS, PhD, professor in the oral and maxillofacial pathology department at Tufts University School of Dental Medicine and a member of the cell, molecular & developmental biology program faculty at the Sackler School of Biomedical Sciences at Tufts. Garlick is also the director of the Center for Integrated Tissue Engineering (CITE) at Tufts University School of Dental Medicine, which is dedicated to furthering the understanding of regenerative medicine through the investigation of three-dimensional tissue models.

Solomon has authored four studies on CUS since 2003. In March 2010, she was the lead author on a study examining the effectiveness of a simpler and less expensive diagnostic tool for CUS that is in development with colleagues from TUSDM, Tufts University School of Medicine, and Beutner Laboratories.


Story Source:

The above story is based on materials provided by Tufts University, Health Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mark W. Carlson, Jonathan A. Garlick, Lynn W. Solomon. Chronic ulcerative stomatitis: evidence of autoimmune pathogenesis. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2011; DOI: 10.1016/j.tripleo.2010.12.020

Cite This Page:

Tufts University, Health Sciences. "New evidence that chronic ulcerative stomatitis is an autoimmune disease." ScienceDaily. ScienceDaily, 14 April 2011. <www.sciencedaily.com/releases/2011/04/110413093225.htm>.
Tufts University, Health Sciences. (2011, April 14). New evidence that chronic ulcerative stomatitis is an autoimmune disease. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2011/04/110413093225.htm
Tufts University, Health Sciences. "New evidence that chronic ulcerative stomatitis is an autoimmune disease." ScienceDaily. www.sciencedaily.com/releases/2011/04/110413093225.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins