Featured Research

from universities, journals, and other organizations

New evidence that chronic ulcerative stomatitis is an autoimmune disease

Date:
April 14, 2011
Source:
Tufts University, Health Sciences
Summary:
In a study investigating the cause of a little-understood condition called chronic ulcerative stomatitis (CUS), researchers have provided evidence that an autoimmune response contributes to the painful oral disease, supporting the classification of CUS as an autoimmune disease.

In the first study investigating the origins of a little-known condition called chronic ulcerative stomatitis (CUS), researchers at Tufts University School of Dental Medicine provide evidence that an autoimmune response contributes to the painful oral sores that characterize the disease. The study findings support the classification of CUS as a new autoimmune disease.

Chronic ulcerative stomatitis is characterized by painful, recurring sores in the mouth. Thus far, it has been diagnosed most frequently in white women in their 40's and 50's and may appear similar to oral erosive lichen planus. Only 39 cases of CUS have been reported in the English-language medical literature since it was identified as a clinically distinct condition in 1989, but it is likely under-diagnosed because of low awareness among clinicians and the extensiveness of the testing that would confirm its presence.

"Currently, diagnosing CUS requires a surgical biopsy which then must be sent to an outside lab for special processing for immunofluorescence microscopic examination. Accurate diagnosis is important because the usual treatment option for immunologically-mediated diseases, corticosteroids, is often not effective in treating CUS," said senior author, Lynn Solomon, DDS, MS, associate professor in the department of oral and maxillofacial pathology at Tufts University School of Dental Medicine (TUSDM).

"In previous studies, we identified that CUS patients had specific autoantibodies -antibodies produced by an immune response to the body's own tissue -- but we weren't sure whether these autoantibodies were contributing to CUS or part of a benign biological process. In this study, we determined that autoantibodies fulfill the criteria of pathogenetic antibodies and do contribute to the disease," she continued.

In this in vitro study, the researchers applied antibodies from four CUS patients to Human Skin Equivalents (HSEs), a three-dimensional model of skin tissues. At low concentrations, the CUS antibodies appeared to have no effect. At higher concentrations, however, the researchers reported complete detachment of the surface layer of tissue, known as epithelium.

The researchers found that the CUS autoantibodies do not cause damage to the surface epithelial cells, but cause a change in the cell-binding proteins that allow the surface layer to attach to the connective tissue beneath them. This weakened cohesion results in breakdown of the tissue, which would result in the sores that characterize CUS.

"In our future research, we would like to gain a better understanding of the mechanisms linking the autoimmune response to ulcerative sores so that we can optimize approaches to managing the condition. Additional data will help us evaluate hydroxychloroquine therapy, an antimalarial drug used off-label that provides relief in many cases, but which is not well-tolerated by some patients and which may have serious side effects," said Solomon.

The first author on the paper, Mark Carlson, PhD, now at Organogenesis, Inc., is an alumnus of the Training in Education and Critical Research Skills (TEACRS) program at Tufts, where he was a fellow in Jonathan Garlick's lab at TUSDM. TEACRS, funded by the National Institute of General Biomedical Sciences, part of the National Institutes of Health, is a program that fosters academic biomedical research and education leaders.

An additional author is Jonathan Garlick, DDS, PhD, professor in the oral and maxillofacial pathology department at Tufts University School of Dental Medicine and a member of the cell, molecular & developmental biology program faculty at the Sackler School of Biomedical Sciences at Tufts. Garlick is also the director of the Center for Integrated Tissue Engineering (CITE) at Tufts University School of Dental Medicine, which is dedicated to furthering the understanding of regenerative medicine through the investigation of three-dimensional tissue models.

Solomon has authored four studies on CUS since 2003. In March 2010, she was the lead author on a study examining the effectiveness of a simpler and less expensive diagnostic tool for CUS that is in development with colleagues from TUSDM, Tufts University School of Medicine, and Beutner Laboratories.


Story Source:

The above story is based on materials provided by Tufts University, Health Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mark W. Carlson, Jonathan A. Garlick, Lynn W. Solomon. Chronic ulcerative stomatitis: evidence of autoimmune pathogenesis. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2011; DOI: 10.1016/j.tripleo.2010.12.020

Cite This Page:

Tufts University, Health Sciences. "New evidence that chronic ulcerative stomatitis is an autoimmune disease." ScienceDaily. ScienceDaily, 14 April 2011. <www.sciencedaily.com/releases/2011/04/110413093225.htm>.
Tufts University, Health Sciences. (2011, April 14). New evidence that chronic ulcerative stomatitis is an autoimmune disease. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/04/110413093225.htm
Tufts University, Health Sciences. "New evidence that chronic ulcerative stomatitis is an autoimmune disease." ScienceDaily. www.sciencedaily.com/releases/2011/04/110413093225.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins