Featured Research

from universities, journals, and other organizations

Anti-aging hormone Klotho inhibits renal fibrosis, cancer growth

Date:
April 14, 2011
Source:
UT Southwestern Medical Center
Summary:
A natural hormone known to inhibit aging can also protect kidneys against renal fibrosis researchers have demonstrated.

A natural hormone known to inhibit aging can also protect kidneys against renal fibrosis, UT Southwestern Medical Center researchers have demonstrated.

Scientists led by Dr. Makoto Kuro-o, associate professor of pathology, showed in mice that the anti-aging hormone Klotho suppressed both renal fibrosis -- a common complication of chronic kidney disease -- and the spread of cancer. The findings are available online in the Journal of Biological Chemistry.

More than 26 million people in the U.S. are affected by chronic kidney disease. Researchers say Klotho also helps patients with acute injury of the kidney that obstructs urine outflow or causes a drop in blood flow to the kidney. Nearly half of the patients in hospital intensive care units have some form of kidney injury due to drugs, surgery, bleeding or dehydration, said Dr. Kuro-o, the study's senior author who discovered Klotho more than a decade ago.

"Within a few days after injury, renal function can be completely gone," he said. "We show that Klotho injection in a drip infusion could be effective not only as an initial treatment for acute kidney injury, but also to prevent its progression into chronic kidney disease. This offers real hope for patients with renal disease."

The UT Southwestern researchers focused on mesenchymal cells: multipotent cells that can differentiate into a variety of cell types. These are essential for development and growth, but when the cells are out of balance, they can morph into a pathological form that causes fibrosis (toughening of the tissue layers) and metastasis in cancer cells, said Dr. Kuro-o.

Scientists involved in this study also found that Klotho prevents cancer migration and metastasis. In the study, they blocked a ureter to cause renal fibrosis or introduced human cancer cells in laboratory mice. Secreted Klotho was effective in blocking three signaling pathways -- TGF-β1, Wnt and IGF-1 -- that can cause tissue fibrosis or cancer metastasis.

The researchers reported for the first time that Klotho binds to the cells' transforming growth factor receptor and inhibits signaling required for epithelial-to-mesenchymal transition (EMT), a "master switch" that causes cells to morph into a more pliable form. EMT cancer cells can squeeze into surrounding tissue and eventually into the bloodstream, leading to metastatic spreading of cancer.

"This is further evidence that Klotho is an understudied tumor-suppressor and really quite important because it's secreted and flows through the body," said Dr. David Boothman, professor of radiation oncology and pharmacology, associate director for translational research and an author of the study. "It could be a major surveillance mechanism for blocking tumor formation and progression."

Other UT Southwestern researchers involved in the study were lead author Dr. Shigehiro Doi, former postdoctoral researcher in pathology now at Hiroshima University in Japan; co-lead author Dr. Yonglong Zou, research associate in the Harold C. Simmons Comprehensive Cancer Center; Dr. Osamu Togao, postdoctoral researcher in the Advanced Imaging Research Center (AIRC); Johanne Pastor, senior research associate in pathology; Dr. George John, instructor of pathology; Lei Wang, research assistant in pathology; Dr. Kazuhiro Shizaki, instructor of pathology; and Dr. Masaya Takahashi, associate professor of radiology and in the AIRC.

Funding for the study was provided in part by grants from the National Institutes of Health, the Department of Energy, Genzyme Corp. and Philips Japan.


Story Source:

The above story is based on materials provided by UT Southwestern Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

UT Southwestern Medical Center. "Anti-aging hormone Klotho inhibits renal fibrosis, cancer growth." ScienceDaily. ScienceDaily, 14 April 2011. <www.sciencedaily.com/releases/2011/04/110413171333.htm>.
UT Southwestern Medical Center. (2011, April 14). Anti-aging hormone Klotho inhibits renal fibrosis, cancer growth. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2011/04/110413171333.htm
UT Southwestern Medical Center. "Anti-aging hormone Klotho inhibits renal fibrosis, cancer growth." ScienceDaily. www.sciencedaily.com/releases/2011/04/110413171333.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) — A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins