Featured Research

from universities, journals, and other organizations

Controversial TOFT theory of cancer versus SMT model: Experts debate

Date:
April 15, 2011
Source:
Wiley-Blackwell
Summary:
Cancer scientists pit their controversial tissue organization field theory of the origin of cancer against the widely accepted somatic mutation theory in what is believed to be the first time the two theories have formally opposed each other in a forum for discussion.

Writing in BioEssays, cancer scientists Ana Soto and Carlos Sonnenschein pit their controversial Tissue Organization Field Theory (TOFT) of the origin of cancer against the widely accepted Somatic Mutation Theory (SMT) in what is believed to be the first time the two theories have formally opposed each other -- championed by authors from opposite sides of the debate -- in a common forum for discussion.

Related Articles


Soto and Sonnenschein, from Tufts University, argue that SMT, which is based on the accumulation of genetic mutations in cells, not only fails to provide an explanation for observable phenomena in cancer biology, but with current technologies it is essentially untestable.

The TOFT theory proposes that cancer is a clonal, cell-based disease, and implicitly assumes that quiescence is the default state of cells in multicellular organisms.

"SMT is strongly supported by observations of leukemias that bear specific chromosome translocations," writes Dr David Vaux, from La Trobe Institute for Molecular Science, Australia, in defence of SMT. "Perhaps the strongest validation comes from the successful treatment of certain malignancies with drugs that directly target the product of the mutant gene."

"This appears to be the first time that the TOFT has formally gone head-to-head with the SMT in a common arena" said BioEssays, Editor-in-Chief Andrew Moore.

"BioEssays believes that science advances through the clear exposition of contrary views, and has created a new forum for vigorous debate which addresses the fundamental basis of cancer: may our readers decide for themselves!" adds David Thomas, BioEssays, Editorial Board Member, and co-editor of the Point<>Counterpoint pair.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal References:

  1. David L. Vaux. In defense of the somatic mutation theory of cancer. BioEssays, 2011; 33 (5): 341 DOI: 10.1002/bies.201100022
  2. Ana M. Soto, Carlos Sonnenschein. The tissue organization field theory of cancer: A testable replacement for the somatic mutation theory. BioEssays, 2011; 33 (5): 332 DOI: 10.1002/bies.201100025

Cite This Page:

Wiley-Blackwell. "Controversial TOFT theory of cancer versus SMT model: Experts debate." ScienceDaily. ScienceDaily, 15 April 2011. <www.sciencedaily.com/releases/2011/04/110415083217.htm>.
Wiley-Blackwell. (2011, April 15). Controversial TOFT theory of cancer versus SMT model: Experts debate. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2011/04/110415083217.htm
Wiley-Blackwell. "Controversial TOFT theory of cancer versus SMT model: Experts debate." ScienceDaily. www.sciencedaily.com/releases/2011/04/110415083217.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins