Featured Research

from universities, journals, and other organizations

Controversial TOFT theory of cancer versus SMT model: Experts debate

Date:
April 15, 2011
Source:
Wiley-Blackwell
Summary:
Cancer scientists pit their controversial tissue organization field theory of the origin of cancer against the widely accepted somatic mutation theory in what is believed to be the first time the two theories have formally opposed each other in a forum for discussion.

Writing in BioEssays, cancer scientists Ana Soto and Carlos Sonnenschein pit their controversial Tissue Organization Field Theory (TOFT) of the origin of cancer against the widely accepted Somatic Mutation Theory (SMT) in what is believed to be the first time the two theories have formally opposed each other -- championed by authors from opposite sides of the debate -- in a common forum for discussion.

Related Articles


Soto and Sonnenschein, from Tufts University, argue that SMT, which is based on the accumulation of genetic mutations in cells, not only fails to provide an explanation for observable phenomena in cancer biology, but with current technologies it is essentially untestable.

The TOFT theory proposes that cancer is a clonal, cell-based disease, and implicitly assumes that quiescence is the default state of cells in multicellular organisms.

"SMT is strongly supported by observations of leukemias that bear specific chromosome translocations," writes Dr David Vaux, from La Trobe Institute for Molecular Science, Australia, in defence of SMT. "Perhaps the strongest validation comes from the successful treatment of certain malignancies with drugs that directly target the product of the mutant gene."

"This appears to be the first time that the TOFT has formally gone head-to-head with the SMT in a common arena" said BioEssays, Editor-in-Chief Andrew Moore.

"BioEssays believes that science advances through the clear exposition of contrary views, and has created a new forum for vigorous debate which addresses the fundamental basis of cancer: may our readers decide for themselves!" adds David Thomas, BioEssays, Editorial Board Member, and co-editor of the Point<>Counterpoint pair.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal References:

  1. David L. Vaux. In defense of the somatic mutation theory of cancer. BioEssays, 2011; 33 (5): 341 DOI: 10.1002/bies.201100022
  2. Ana M. Soto, Carlos Sonnenschein. The tissue organization field theory of cancer: A testable replacement for the somatic mutation theory. BioEssays, 2011; 33 (5): 332 DOI: 10.1002/bies.201100025

Cite This Page:

Wiley-Blackwell. "Controversial TOFT theory of cancer versus SMT model: Experts debate." ScienceDaily. ScienceDaily, 15 April 2011. <www.sciencedaily.com/releases/2011/04/110415083217.htm>.
Wiley-Blackwell. (2011, April 15). Controversial TOFT theory of cancer versus SMT model: Experts debate. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2011/04/110415083217.htm
Wiley-Blackwell. "Controversial TOFT theory of cancer versus SMT model: Experts debate." ScienceDaily. www.sciencedaily.com/releases/2011/04/110415083217.htm (accessed April 19, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, April 19, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Newsy (Apr. 17, 2015) Ten doctors signed a letter urging Columbia University to drop Dr. Oz as vice chair of its department of surgery, saying he plugs "quack" treatments. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins