Featured Research

from universities, journals, and other organizations

Inhaled corticosteroid therapy reduces pneumonia mortality, large study finds

Date:
April 15, 2011
Source:
American Thoracic Society
Summary:
Patients with chronic obstructive pulmonary disease (COPD) who are hospitalized for pneumonia and treated with inhaled corticosteroids (ICS) have decreased mortality when compared to those who are not treated with ICS, according to a retrospective analysis of almost 16,000 COPD patients admitted to VA hospitals.

Patients with chronic obstructive pulmonary disease (COPD) who are hospitalized for pneumonia and treated with inhaled corticosteroids (ICS) have decreased mortality when compared to those who are not treated with ICS, according to a retrospective analysis of almost 16,000 COPD patients admitted to VA hospitals.

Related Articles


The results were published online ahead of the print edition of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

The use of ICS in COPD patients reduces exacerbations, but increases the rate pneumonia. "It was therefore believed that it also increased mortality," said Eric Mortensen, MD, investigator at VERDICT (Veterans Evidence-based Research, Dissemination, and Implementation Center, a VA Health Services Research and Development program) and principal investigator on the study. "This was the first large rigorous study to examine whether this was in fact the case."

"This result is the opposite of what many experts have believed," said Dr. Mortensen. "We do, however, believe that this represents the reality because ours is one the largest studies, and employed a rigorous definition of pneumonia that previous studies did not."

Dr. Mortensen and colleagues examined the medical records of 15,768 COPD patients over the age of 65 who had been admitted to the VA hospitals for pneumonia between 2002 and 2007. About half of those patients had been treated with ICS (52.5 percent) and half were not (47.5 percent).

When they analyzed all-cause mortality of the two groups for both 30- and 90-day intervals, there were significant differences between the groups: for 30-day mortality, 10.2 percent of ICS users died, compared to 13.6 percent of those who were not treated with ICS. For 90-day mortality, the difference was even more striking: 17.3 percent among the ICS users died, and 22.8 percent of those who didn't receive ICS.

Overall, those who were not treated with ICS had about a 25 percent greater mortality risk than those who were treated with ICS.

"These results have clear implications for current clinical practice, which has been informed in the past by a series of studies that found an increased risk of pneumonia with ICS use," said Dr. Mortensen. "In contrast, our study would suggest that ICS use may confer a survival benefit to these patients and may be employed when there are not contraindications. These results should reassure clinicians that they can give their COPD patients ICS without fearing that the increased risk of pneumonia will translate into higher risk of mortality."

The next "really big question," according to Dr. Mortensen is whether ICS might be useful to initiate in certain sub-populations hospitalized with pneumonia. "There is currently a large randomized, controlled trial getting started that is looking at using oral versus intravenous steroids for all pneumonia patients," Dr. Mortensen explained. "The potential question is if this is successful would it be as useful to start these patients on inhaled (rather than oral or intravenous) steroids."


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "Inhaled corticosteroid therapy reduces pneumonia mortality, large study finds." ScienceDaily. ScienceDaily, 15 April 2011. <www.sciencedaily.com/releases/2011/04/110415124053.htm>.
American Thoracic Society. (2011, April 15). Inhaled corticosteroid therapy reduces pneumonia mortality, large study finds. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2011/04/110415124053.htm
American Thoracic Society. "Inhaled corticosteroid therapy reduces pneumonia mortality, large study finds." ScienceDaily. www.sciencedaily.com/releases/2011/04/110415124053.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins