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Intellectual disability is frequently caused by non-hereditary genetic problems, study finds

Date:
April 25, 2011
Source:
University of Montreal
Summary:
Mutations in a group of genes associated with brain activity frequently cause intellectual disability, according to a new study.

Mutations in a group of genes associated with brain activity frequently cause intellectual disability, according to a study led by scientists affiliated with the University of Montreal and the research centre at the Centre hospitalier universitaire Sainte-Justine.

Intellectual disability is a severe handicap that affects between one and two percent of children worldwide. It can often be attributed to genetic causes, but the specific genes involved were mostly unknown. "The group of genes we identified all play important roles in nerve synapses, the structures that allow brain cells to rapidly transfer information," explained senior author Dr. Jacques Michaud. "These findings indicate that, in this case, intellectual disability occurs because there is a disruption in nerve cell communication."

Some intellectual disabilities are associated with physical abnormalities that indicate major genetic abnormalities. However, in other cases disabilities are not associated with obvious physical traits "We targeted non-syndromic patients," Michaud said. Together with his colleagues from the Synapse to Disease Project, Michaud analyzed DNA from the patients to identify mutations that were not inherited but were in fact newly formed. These are called de novo mutations. They studied 197 synaptic genes and identified de novo mutations in 10 of the 95 patients. Further studies indicated that all of these mutations affect nerve cell communication, which lead the team to conclude that at least two-thirds of the mutations are the definitive cause of the disorder.

"This finding aligns with our previous work that shows that de novo mutations play important roles in disorders such as autism and schizophrenia," said co-author Guy Rouleau. "Our study indicates that a large fraction of cases with intellectual disability have a genetic origin but are not hereditary. These findings will lead to improved diagnostics," added co-author Fadi Hamdan.

The study was published in the American Journal of Human Genetics and received financing from the Canadian Institutes of Health Research. Centre hospitalier universitaire Sainte-Justine (CHUSJ) and Centre hospitalier de l'Université de Montréal (CHUM) can be translated to Saint-Justine University Hospital Centre and University of Montreal Hospital Centre, respectively. Michaud, Rouleau and Hamdan are affiliated with the University of Montreal's Centre of Excellence in Neuromics and the CHUSJ Research Centre. Rouleau is the Director of the CHUSJ Research Centre and is also affiliated with the University of Montreal's Department of Medicine.


Story Source:

The above story is based on materials provided by University of Montreal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fadi F. Hamdan, Julie Gauthier, Yoichi Araki, Da-Ting Lin, Yuhki Yoshizawa, Kyohei Higashi, A-Reum Park, Dan Spiegelman, Sylvia Dobrzeniecka, Amélie Piton. Excess of De Novo Deleterious Mutations in Genes Associated with Glutamatergic Systems in Nonsyndromic Intellectual Disability. The American Journal of Human Genetics, 2011; 88 (3): 306 DOI: 10.1016/j.ajhg.2011.02.001

Cite This Page:

University of Montreal. "Intellectual disability is frequently caused by non-hereditary genetic problems, study finds." ScienceDaily. ScienceDaily, 25 April 2011. <www.sciencedaily.com/releases/2011/04/110418114005.htm>.
University of Montreal. (2011, April 25). Intellectual disability is frequently caused by non-hereditary genetic problems, study finds. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2011/04/110418114005.htm
University of Montreal. "Intellectual disability is frequently caused by non-hereditary genetic problems, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/04/110418114005.htm (accessed April 24, 2014).

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