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Adaptive trial designs could accelerate HIV vaccine development

Date:
April 20, 2011
Source:
NIH/National Institute of Allergy and Infectious Diseases
Summary:
In the past 12 years, four large-scale efficacy trials of HIV vaccines have been conducted in various populations. Results from the most recent trial have given scientists reason for cautious optimism. Yet building on these findings could take years, given that traditional HIV vaccine clinical trials are lengthy, and that it is still not known which immune system responses a vaccine needs to trigger to protect an individual from HIV infection.

In the past 12 years, four large-scale efficacy trials of HIV vaccines have been conducted in various populations. Results from the most recent trial -- the RV144 trial in Thailand, which found a 31 percent reduction in the rate of HIV acquisition among vaccinated heterosexual men and women -- have given scientists reason for cautious optimism.

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Yet building on these findings could take years, given that traditional HIV vaccine clinical trials are lengthy, and that it is still not known which immune system responses a vaccine needs to trigger to protect an individual from HIV infection.

To accelerate HIV vaccine development, scientists working at and funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, propose using adaptive clinical trial designs. These designs allow a trial to be modified in response to data acquired during the study. Such trials would rapidly screen out poor vaccine candidates, enable extended evaluation of promising candidates and provide key information on the immunological basis for HIV prevention.

In a paper appearing in Science Translational Medicine, the scientists review the four major HIV vaccine trials undertaken thus far and the scientific questions and challenges that remain. They describe what is needed to advance HIV vaccines through clinical trials and how adaptive clinical trial designs may accelerate identification of an effective HIV vaccine.


Story Source:

The above story is based on materials provided by NIH/National Institute of Allergy and Infectious Diseases. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. Corey, G. J. Nabel, C. Dieffenbach, P. Gilbert, B. F. Haynes, M. Johnston, J. Kublin, H. C. Lane, G. Pantaleo, L. J. Picker, A. S. Fauci. HIV-1 Vaccines and Adaptive Trial Designs. Science Translational Medicine, 2011; 3 (79): 79ps13 DOI: 10.1126/scitranslmed.3001863

Cite This Page:

NIH/National Institute of Allergy and Infectious Diseases. "Adaptive trial designs could accelerate HIV vaccine development." ScienceDaily. ScienceDaily, 20 April 2011. <www.sciencedaily.com/releases/2011/04/110420143658.htm>.
NIH/National Institute of Allergy and Infectious Diseases. (2011, April 20). Adaptive trial designs could accelerate HIV vaccine development. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2011/04/110420143658.htm
NIH/National Institute of Allergy and Infectious Diseases. "Adaptive trial designs could accelerate HIV vaccine development." ScienceDaily. www.sciencedaily.com/releases/2011/04/110420143658.htm (accessed December 18, 2014).

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