Featured Research

from universities, journals, and other organizations

Diabetic kidney disease: PVT1 is associated with proteins responsible for reduced blood filtration

Date:
April 24, 2011
Source:
The Translational Genomics Research Institute
Summary:
A gene called PVT1 may help reduce the kidneys ability to filter blood, leading to kidney disease, kidney failure and death, according to a new study.

A gene called PVT1 may help reduce the kidneys ability to filter blood, leading to kidney disease, kidney failure and death, according to a study published by researchers at the Translational Genomics Research Institute (TGen).

The TGen team found PVT1 expression levels increased up to 5-fold in response to hyperglycemia, or high blood sugar, a condition that often accompanies diabetes.

But by knocking down or reducing the expression of the PVT1gene, TGen researchers lowered the amount of proteins associated with the excessive accumulation of extracellular matrix (ECM) in glomeruli, part of the basic filtration unit of kidneys, according to the TGen study appearing in the online scientific journal PLoS ONE, published by the Public Library of Science.

The accumulation of excessive ECM within the mesangial cells, which regulate blood flow in capillaries inside the kidney, is a hallmark of diabetic nephropathy, or kidney disease, which is the leading cause of reduced life expectancy among the nation's growing numbers of diabetics.

"The goal of this study was to identify possible molecular mechanisms by which PVT1 may contribute to the development and progression of diabetic nephropathy in mesangial cells," said Dr. Johanna DiStefano, the study's senior author and Director of TGen's Diabetes, Cardiovascular and Metabolic Diseases Center.

"Despite the growing magnitude of the disease, the molecular mechanisms underlying the etiology of diabetic nephropathy remain poorly understood," Dr. DiStefano said.

PVT1, also known as plasmacytoma variant translocation 1, was previously identified by Dr. DiStefano's team as a candidate gene for End Stage Renal Disease (ESRD), or kidney failure. Too much PVT1 also has been associated with breast and ovarian cancers, in which it may help cause cells to multiply out of control and fail to go through the normal process of cellular death.

Through RNA interference, which helps control which genes are active and the degree of their activity, researchers reduced the expression of PVT1, which in turn reduced the protein levels of ECM components.

In a related finding, TGen scientists discovered that PVT1 affects the expression of other genes -- FN1, COL4A1 and PAI-1 -- in a manner that is at least partially independent of TFFB1, a gene associated with tissue fibrosis, or tissue damage.

"Delineation of the relationship between TGFB1 and PVT1 represents a critical component toward understanding the molecular mechanisms underlying the regulation of ECM in diabetic nephropathy," said Dr. Lucrecia Alvarez, the study's lead author and a TGen post-doctoral fellow.

Funding for the study was provided, in part, by the American Diabetes Association.


Story Source:

The above story is based on materials provided by The Translational Genomics Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Lucrecia Alvarez, Johanna K. DiStefano. Functional Characterization of the Plasmacytoma Variant Translocation 1 Gene (PVT1) in Diabetic Nephropathy. PLoS ONE, 2011; 6 (4): e18671 DOI: 10.1371/journal.pone.0018671

Cite This Page:

The Translational Genomics Research Institute. "Diabetic kidney disease: PVT1 is associated with proteins responsible for reduced blood filtration." ScienceDaily. ScienceDaily, 24 April 2011. <www.sciencedaily.com/releases/2011/04/110424152455.htm>.
The Translational Genomics Research Institute. (2011, April 24). Diabetic kidney disease: PVT1 is associated with proteins responsible for reduced blood filtration. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2011/04/110424152455.htm
The Translational Genomics Research Institute. "Diabetic kidney disease: PVT1 is associated with proteins responsible for reduced blood filtration." ScienceDaily. www.sciencedaily.com/releases/2011/04/110424152455.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins