Featured Research

from universities, journals, and other organizations

Medication nonadherence patterns among children with epilepsy associated with socioeconomic status

Date:
April 26, 2011
Source:
JAMA and Archives Journals
Summary:
An examination of medication adherence among children with newly diagnosed epilepsy found that nearly 60 percent showed persistent nonadherence during the first 6 months of therapy, and that lower socioeconomic status was associated with higher non-adherence, according to a new study.

An examination of medication adherence among children with newly diagnosed epilepsy found that nearly 60 percent showed persistent nonadherence during the first 6 months of therapy, and that lower socioeconomic status was associated with higher non-adherence, according to a study in the April 27 issue of JAMA.

Epilepsy, a disorder of recurrent unprovoked seizures, affects 325,000 children younger than 15 years in the United States. "Because of epilepsy's common occurrence, the narrow therapeutic and safety margins of antiepileptic medications, and the recognized complications of medication non-adherence in adults with epilepsy, identifying the rates, patterns, and predictors of non-adherence in children with epilepsy is imperative. The onset and evolution of antiepileptic drug nonadherence in children with newly diagnosed epilepsy remains unknown," according to background information in the article.

Avani C. Modi, Ph.D., of Cincinnati Children's Hospital Medical Center, Cincinnati, and colleagues conducted a study to identify and characterize medication adherence trajectories over the first 6 months of therapy for children with new-onset epilepsy using electronic monitors and to identify sociodemographic and epilepsy-specific predictors of adherence trajectories. The study included 124 children (2-12 years old) with final data collection through September 2009. Adherence was measured electronically with a system in which the cap of the medication bottle contained a microelectronic circuit to register the dates and times the bottle was opened and closed.

Of the children in the study, 58 percent demonstrated persistent nonadherence during the first 6 months of therapy. The researchers identified 5 different adherence patterns with group-based trajectory models. The 5 groups, based on severity and course of non-adherence, were severe early nonadherence (n= 16; 13 percent), severe delayed nonadherence (n = 8; 7 percent), moderate nonadherence (n= 16; 13 percent), mild nonadherence (n = 32; 26 percent), and near-perfect adherence (n = 52; 42 percent).

"The adherence pattern of most patients was established by the first month of therapy. Socioeconomic status was the sole predictor of adherence trajectory group status, with lower socioeconomic status associated with higher non-adherence," the authors write.

"Socioeconomic status was the only significant predictor of nonadherence and may help identify patients at highest risk. Given that nonadherence is frequent, may compromise the benefits of drug therapy, may complicate interpretation of clinical response, and can be addressed through evidence-based interventions, clinicians should consider routinely assessing adherence to antiepileptic drug therapy in all children with epilepsy."

"…the rate of nonadherence over the course of the first 6 months of therapy is concerning and suggests a need for intervention studies that aim to optimize adherence early in the course of therapy," the researchers conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Avani C. Modi, Joseph R. Rausch and Tracy A. Glauser. Patterns of Nonadherence to Antiepileptic Drug Therapy in Children With Newly Diagnosed Epilepsy. JAMA, 2011;305(16):1669-1676 DOI: 10.1001/jama.2011.506

Cite This Page:

JAMA and Archives Journals. "Medication nonadherence patterns among children with epilepsy associated with socioeconomic status." ScienceDaily. ScienceDaily, 26 April 2011. <www.sciencedaily.com/releases/2011/04/110426161524.htm>.
JAMA and Archives Journals. (2011, April 26). Medication nonadherence patterns among children with epilepsy associated with socioeconomic status. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2011/04/110426161524.htm
JAMA and Archives Journals. "Medication nonadherence patterns among children with epilepsy associated with socioeconomic status." ScienceDaily. www.sciencedaily.com/releases/2011/04/110426161524.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins