Featured Research

from universities, journals, and other organizations

New mitochondrial control mechanism discovered

Date:
May 4, 2011
Source:
Karolinska Institutet
Summary:
Scientists have discovered a new component of mitochondria that plays a key part in their function. The discovery is of potential significance to our understanding of both inherited and age-related diseases.

Scientists have discovered a new component of mitochondria that plays a key part in their function. The discovery, which is presented in the journal Cell Metabolism, is of potential significance to our understanding of both inherited and age-related diseases.

Related Articles


Mitochondria are normally called the cell's power plants since they convert the energy in our food into a form that the body can use. To work properly, the mitochondria have to form new proteins, which they do in their ribosomes.

A group of researchers at Karolinska Institutet in Sweden and the Max Planck Institute for Biology of Ageing, Germany, has discovered that a protein called MTERF4 combines with another protein called NSUN4 to form a complex that controls the formation and function of the mitochondrial ribosomes. In mice lacking MTERF4 no functional ribosomes are formed, leading to a reduction in energy production.

"Reduced mitochondrial function is involved in several inherited diseases, normal aging and age-related diseases," says Professor Nils Gφran Larsson, who co-led the study with Professor Claes Gustafsson. "Fundamental knowledge of how mitochondrial function is regulated can therefore be of great clinical significance in the future."

The research group previously discovered similar regulation mechanisms in the mitochondria that were found to be related to the development of diabetes.


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yolanda Cαmara, Jorge Asin-Cayuela, Chan Bae Park, Metodi D. Metodiev, Yonghong Shi, Benedetta Ruzzenente, Christian Kukat, Bianca Habermann, Rolf Wibom, Kjell Hultenby, Thomas Franz, Hediye Erdjument-Bromage, Paul Tempst, B. Martin Hallberg, Claes M. Gustafsson, Nils-Gφran Larsson. MTERF4 Regulates Translation by Targeting the Methyltransferase NSUN4 to the Mammalian Mitochondrial Ribosome. Cell Metabolism, 2011; 13 (5): 527-539 DOI: 10.1016/j.cmet.2011.04.002

Cite This Page:

Karolinska Institutet. "New mitochondrial control mechanism discovered." ScienceDaily. ScienceDaily, 4 May 2011. <www.sciencedaily.com/releases/2011/05/110504080726.htm>.
Karolinska Institutet. (2011, May 4). New mitochondrial control mechanism discovered. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2011/05/110504080726.htm
Karolinska Institutet. "New mitochondrial control mechanism discovered." ScienceDaily. www.sciencedaily.com/releases/2011/05/110504080726.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) — Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com
New Hormone Could Protect Against Diabetes And Weight Gain

New Hormone Could Protect Against Diabetes And Weight Gain

Newsy (Mar. 4, 2015) — A newly discovered hormone mimics the effects of exercise, protecting against diabetes and weight gain. Video provided by Newsy
Powered by NewsLook.com
Mount Everest Has a Poop Problem

Mount Everest Has a Poop Problem

Buzz60 (Mar. 4, 2015) — With no bathrooms to use, climbers of Mount Everest have been leaving human waste on the mountain for years, and it&apos;s becoming a health issue. Mike Janela (@mikejanela) has more. Video provided by Buzz60
Powered by NewsLook.com
The Best Tips to 'Skinny' Your Home

The Best Tips to 'Skinny' Your Home

Buzz60 (Mar. 4, 2015) — If you&apos;re looking to reach your health goals this season, there are a few simple tips to help you spring clean your space and improve your nutrition. Krystin Goodwin (@krystingoodwin) has the skinny on keeping a healthy home. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins