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Patients often do not receive optimal medical therapy before and after percutaneous coronary intervention

Date:
May 10, 2011
Source:
JAMA and Archives Journals
Summary:
Despite guideline-based recommendations that underscore the importance of optimal medical therapy (OMT) for patients with stable coronary heart disease undergoing percutaneous coronary intervention (PCI; procedures such as balloon angioplasty or stent placement used to open narrowed coronary arteries), data from a cardiovascular registry indicate that less than half of these patients are receiving OMT before PCI and approximately one-third are not receiving OMT at discharge following PCI, according to a new study.

Despite guideline-based recommendations that underscore the importance of optimal medical therapy (OMT) for patients with stable coronary heart disease undergoing percutaneous coronary intervention (PCI; procedures such as balloon angioplasty or stent placement used to open narrowed coronary arteries), data from a cardiovascular registry indicate that less than half of these patients are receiving OMT before PCI and approximately one-third are not receiving OMT at discharge following PCI, according to a study in the May 11 issue of JAMA.

Although PCI may improve outcomes for patients with acute coronary syndrome, OMT results in similar rates of cardiovascular events when compared with PCI in patients with stable coronary artery disease (CAD). Findings of a meta-analysis of 11 trials concluded that there was no benefit of PCI in preventing heart attack or death in patients with stable CAD. In addition, the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) study, which provided OMT to all patients, demonstrated no incremental advantage of PCI on outcomes other than angina-related quality of life in stable CAD, suggesting that a trial of OMT is warranted before PCI. "It is unknown to what degree OMT is applied before PCI in routine practice or whether its use increased after the COURAGE trial," according to background information in the article.

William B. Borden, M.D., of Weill Cornell Medical College, Cornell University, New York, and colleagues conducted a study to examine use of OMT before and after PCI and to evaluate whether the use of OMT changed after the publication of the COURAGE trial (March 2007). The study included data from the National Cardiovascular Data Registry of patients with stable CAD undergoing PCI between September 2005 and June 2009. Analysis compared use of OMT, both before PCI and at the time of discharge, and before and after the publication of the COURAGE trial. Optimal medical therapy was defined as either being prescribed or having a documented contraindication to all medicines (antiplatelet agent, beta-blocker, and statin).

A total of 467,211 patients receiving PCI procedures were included in the analysis, with 173,416 patients (37.1 percent) and 293,795 patients (62.9 percent) in the before and after COURAGE periods, respectively. The researchers found that 206,569 patients (44.2 percent) received OMT before PCI and 303,864 patients (65 percent) received OMT at the time of discharge. "Before the COURAGE trial, the rate of OMT at the time of PCI was 43.5 percent. Although the increase in the proportion of patients receiving OMT before PCI after the COURAGE trial was statistically significantly higher, it was of little clinical significance (131,188 patients [44.7 percent]). The rates of OMT before PCI in each study period month showed a small increase during the 46 months of observation, with an OMT rate before PCI of 43.4 percent in September 2005 and an OMT rate after PCI of 45.0 percent in June 2009," the authors write.

The overall rate of OMT after PCI, a time at which the diagnosis of significant obstructive CAD had been confirmed, was 63.5 percent before the COURAGE trial and 66 percent after the COURAGE trial.

"Our study demonstrated that less than half of patients undergoing PCI are taking OMT before their procedure, despite the guideline-based recommendations to maximize OMT and the clinical logic of doing so before PCI so that the need for additional symptom relief from revascularization can be appreciated. Even after publication of the COURAGE trial, little change in this practice pattern was observed. Although clinicians did increase the use of OMT before discharge, with antiplatelet agents being almost universally applied, almost a third of patients were not treated with OMT, a pattern that also did not change after the COURAGE trial was published. Collectively, these findings suggest a significant opportunity for improvement and a limited effect of an expensive, highly publicized clinical trial on routine clinical practice," the authors write.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. W. B. Borden, R. F. Redberg, A. I. Mushlin, D. Dai, L. A. Kaltenbach, J. A. Spertus. Patterns and Intensity of Medical Therapy in Patients Undergoing Percutaneous Coronary Intervention. JAMA: The Journal of the American Medical Association, 2011; 305 (18): 1882 DOI: 10.1001/jama.2011.601

Cite This Page:

JAMA and Archives Journals. "Patients often do not receive optimal medical therapy before and after percutaneous coronary intervention." ScienceDaily. ScienceDaily, 10 May 2011. <www.sciencedaily.com/releases/2011/05/110510161759.htm>.
JAMA and Archives Journals. (2011, May 10). Patients often do not receive optimal medical therapy before and after percutaneous coronary intervention. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2011/05/110510161759.htm
JAMA and Archives Journals. "Patients often do not receive optimal medical therapy before and after percutaneous coronary intervention." ScienceDaily. www.sciencedaily.com/releases/2011/05/110510161759.htm (accessed October 2, 2014).

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