Featured Research

from universities, journals, and other organizations

Elevated protein levels in cardiac muscles could predict mortality following angioplasty

Date:
May 13, 2011
Source:
Wiley-Blackwell
Summary:
New research shows that elevated levels of cardiac troponin T (cTnT) or I (cTnI) in patients who had angioplasty indicate a higher risk of all-cause mortality and long-term adverse events such as heart attack. Routine monitoring of these protein levels following nonemergent percutaneous coronary intervention (PCI) could improve long-term outcomes for these patients.

New research shows that elevated levels of cardiac troponin T (cTnT) or I (cTnI) in patients who had angioplasty indicate a higher risk of all-cause mortality and long-term adverse events such as heart attack. Routine monitoring of these protein levels following nonemergent percutaneous coronary intervention (PCI) could improve long-term outcomes for these patients. Details of the analysis are available online in Catheterization and Cardiovascular Interventions, a peer-reviewed journal of The Society for Cardiovascular Angiography and Interventions (SCAI).

More than one million Americans undergo coronary angioplasty each year to improve blood flow in blocked or narrowed arteries leading to the heart, according to the National Heart, Lung and Blood Institute. In cases where elective PCI was performed medical evidence has found that up to 30% of these patients experience minor elevations in cardiac enzymes, particularly levels of creatine kinase muscle-brain (CK-MB), which are associated with an increase in in-hospital adverse cardiac events. Greater elevations of CK-MB are associated with greater long-term mortality.

Recent studies suggest that elevated levels of cardiac troponins T or I are more specific indicators of cardiac muscle damage than CK-MB. However, conflicting data have been published in medical literature regarding the association between cardiac troponin elevation post-PCI and adverse cardiac events. In the current meta-analysis, Dmitriy Feldman, MD, FSCAI, and colleagues from New York Presbyterian Hospital and Weill Cornell Medical College, assessed the prevalence and mortality risk associated with elevated levels of cTnT or cTnI following elective PCI.

The research team conducted electronic and manual searches of all published studies reporting on the prognostic impact of cTnT or cTnI elevation following elective angioplasty. Twenty-two studies, published between 1998 and 2009, were identified and included 22,353 patients. A meta-analysis -- the largest to date -- of study findings showed that post-PCI levels of cTnT or cTnI were elevated in 26% and 34% of patients, respectively. The follow-up period of participants in the studies analyzed ranged from 3 to 67 months.

"Our analysis demonstrates that post-procedural elevation of cTnT or cTnI provides long-term prognostic information regarding mortality or myocardial infarction," said Dr. Feldman. Results showed that long-term all-cause mortality in patients with elevated cardiac troponin levels after PCI was 5.8% compared to only 4.4% in patients who did not experience an elevation in the cardiac enzymes. Adverse events (death or heart attack) following elective angioplasty were significantly higher in patients with elevated cTnT or cTnI levels (9.2%) compared to those without cTn elevations (5.3%). "Routine monitoring of peri-procedural cTn levels and more intensive outpatient monitoring and treatment of patients with cTn elevations following elective PCI may help to improve long-term adverse outcomes in these patients," Feldman advised.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dmitriy N. Feldman, Luke Kim, A. Garvey Rene, Robert M. Minutello, Geoffrey Bergman and S. Chiu Wong. Prognostic Value of Cardiac Troponin-I or Troponin-T Elevation Following Nonemergent Percutaneous Coronary Intervention: A Meta-analysis. Catheterization and Cardiovascular Interventions, May 13, 2011 DOI: 10.1022/ccd.22962

Cite This Page:

Wiley-Blackwell. "Elevated protein levels in cardiac muscles could predict mortality following angioplasty." ScienceDaily. ScienceDaily, 13 May 2011. <www.sciencedaily.com/releases/2011/05/110513064352.htm>.
Wiley-Blackwell. (2011, May 13). Elevated protein levels in cardiac muscles could predict mortality following angioplasty. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2011/05/110513064352.htm
Wiley-Blackwell. "Elevated protein levels in cardiac muscles could predict mortality following angioplasty." ScienceDaily. www.sciencedaily.com/releases/2011/05/110513064352.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins