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'Clot-busters' no more effective than traditional therapy in treating lung blood clots, study finds

Date:
May 16, 2011
Source:
American Thoracic Society
Summary:
Although so-called clot-busting drugs are commonly used in the treatment of some patients with blood clots in the lungs, a new study conducted by researchers in Spain and the US indicates the agents do not appear to be any more effective than traditional blood thinners for the majority of these patients. Clot-busters, or thrombolytic agents, also appear to increase the risk of death in patients with normal blood pressure.

Although so-called clot-busting drugs are commonly used in the treatment of some patients with blood clots in the lungs, a new study conducted by researchers in Spain and the U.S. indicates the agents do not appear to be any more effective than traditional blood thinners for the majority of these patients. Clot-busters, or thrombolytic agents, also appear to increase the risk of death in patients with normal blood pressure.

The study was presented at the ATS 2011 International Conference in Denver.

"The results of our study do not support the use of thrombolytic, or clot-busting, agents in most patients with acute symptomatic pulmonary embolism," said study author David Jiménez, MD, senior consultant for the respiratory department at the Ramón y Cajal Hospital and Alcalá de Henares University in Madrid.

"We also found that, compared to standard anticoagulation drugs, thrombolytic therapy demonstrated a trend toward increased survival in patients who presented with low blood pressure, while it significantly worsened survival in those without low blood pressure," said Dr. Jiménez, who is also chief of the hospital's pulmonary embolism study group.

The study utilized data from patients enrolled in the Registro Informatizado de la Enfermedad Trombo Embólica (RIETE registry), a computerized registry of patients who have blood clots, including pulmonary blood clots. The researchers reviewed the health information of 15,944 registry-enrolled patients with confirmed symptomatic acute pulmonary embolism to determine if thrombolytic therapy caused an effect on patient mortality during the first three months after diagnosis.

They found that while patients with low blood pressure who were treated with thrombolytic agents had a non-statistically significant reduction in death compared to patients treated with anticoagulants, patients who had normal blood pressure and were treated with thrombolytic drugs had a statistically significant increased risk of death compared to those who received standard anticoagulants.

"The primary finding of the study was expected, as there are no large randomized clinical trials that demonstrate the benefit of thrombolytic therapy on patient survival," Dr. Jiménez said. "However, it was surprising to note that thrombolytic therapy was associated with worsened survival in pulmonary embolism patients with stable blood pressure.

"Unless further information that suggests otherwise becomes available, the guidelines for treatment of patients with pulmonary embolism should not recommend thrombolytic therapy for patients who have normal blood pressure," he said.

Dr. Jiménez said randomized clinical trials should assess the clinical benefit of thrombolysis in selected patients with pulmonary embolism and normal blood pressure.

"Investigators also should conduct prospective studies to assess if cardiac biomarkers and/or imaging testing might identify those patients with low blood pressure who are at highest risk of death and who might benefit from thrombolytic therapy," he said.


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "'Clot-busters' no more effective than traditional therapy in treating lung blood clots, study finds." ScienceDaily. ScienceDaily, 16 May 2011. <www.sciencedaily.com/releases/2011/05/110516111650.htm>.
American Thoracic Society. (2011, May 16). 'Clot-busters' no more effective than traditional therapy in treating lung blood clots, study finds. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2011/05/110516111650.htm
American Thoracic Society. "'Clot-busters' no more effective than traditional therapy in treating lung blood clots, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/05/110516111650.htm (accessed April 20, 2014).

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