Featured Research

from universities, journals, and other organizations

Quicker detection and treatment of severe sepsis

Date:
May 24, 2011
Source:
Lund University
Summary:
Sepsis is the name of an infection that causes a series of reactions in the body, which in the worst case can prove fatal. The problem for both patients and doctors is that the early symptoms are difficult to distinguish from less dangerous infections such as a severe flu or winter vomiting disease. A researcher in Sweden has now discovered a substance in the blood which shows both whether a patient has sepsis and how serious the case is.

Sepsis is the name of an infection that causes a series of reactions in the body, which in the worst case can prove fatal. The problem for both patients and doctors is that the early symptoms are difficult to distinguish from less dangerous infections such as a severe flu or winter vomiting disease. A researcher at Lund University in Sweden has now discovered a substance in the blood which shows both whether a patient has sepsis and how serious the case is.

Related Articles


"Approximately one in five patients with sepsis who are admitted to hospital are at risk of developing severe sepsis within the first 24 hours. If the doctor doesn't immediately understand that the patient is seriously ill, the risk is that he or she does not receive adequate treatment. The patient could also end up on a ward with lower staffing levels and thus less close supervision," says doctor and researcher Adam Linder.

In sepsis (formerly called blood poisoning), the immune system overreacts to an infection, which triggers a series of events in the body. Among other things, the blood vessels begin to leak, resulting in a fall in blood pressure that eventually damages the kidneys, heart and brain. Sepsis is the tenth most common cause of death in the world, and the most common cause of death among already weak patients in hospital intensive care units.

Sepsis is treated with antibiotics, fluids and oxygen. But first, the patients must be diagnosed with sepsis, yet the markers used do not always give a correct diagnosis. Adam Linder has found a better biomarker in protein HBP (heparin-binding protein). This is released by a certain type of white blood cell in amounts which correspond to the immune system's reaction: the greater the overreaction -- and thus the risk of sepsis -- the greater the amount of HBP in the blood of a patient.

Measurements of HBP can also be used in connection with meningitis. There are two forms of the disease, bacterial meningitis and viral meningitis. Again, it is important to get a quick and accurate diagnosis in order to reduce the risk of complications and death. The amount of HBP in a patient's spinal fluid has been shown to provide a more accurate diagnosis than the methods currently used.

However, for HBP measurements to be used successfully in hospitals it must be possible to perform the analysis quickly.

"I analysed my samples in the lab, which took six hours. A doctor in an accident and emergency department cannot wait that long. The time must be reduced to no more than one hour," says Adam Linder.

Hansa Medical, a company in Lund, is currently developing patented methods to quickly analyse HBP in connection with both meningitis and sepsis.

Adam Linder presented his thesis on HBP on 13 May. The title of the thesis is Studies on heparin binding protein in bacterial infections.


Story Source:

The above story is based on materials provided by Lund University. Note: Materials may be edited for content and length.


Cite This Page:

Lund University. "Quicker detection and treatment of severe sepsis." ScienceDaily. ScienceDaily, 24 May 2011. <www.sciencedaily.com/releases/2011/05/110523074823.htm>.
Lund University. (2011, May 24). Quicker detection and treatment of severe sepsis. ScienceDaily. Retrieved January 29, 2015 from www.sciencedaily.com/releases/2011/05/110523074823.htm
Lund University. "Quicker detection and treatment of severe sepsis." ScienceDaily. www.sciencedaily.com/releases/2011/05/110523074823.htm (accessed January 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, January 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

AFP (Jan. 29, 2015) Oxfam International has called for a multi-million dollar post-Ebola "Marshall Plan", with financial support given by wealthy countries, to help Guinea, Sierra Leone and Liberia to recover. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Are We Winning The Fight Against Ebola?

Are We Winning The Fight Against Ebola?

Newsy (Jan. 29, 2015) The World Health Organization announced the fight against Ebola has entered its second phase as the number of cases per week has steadily dropped. Video provided by Newsy
Powered by NewsLook.com
Calif. Health Officials Campaign Against E-Cigarettes

Calif. Health Officials Campaign Against E-Cigarettes

Newsy (Jan. 29, 2015) The California Health Department says e-cigarettes are a public health risk for both smokers and those who inhale e-cig smoke secondhand. Video provided by Newsy
Powered by NewsLook.com
Measles Scare Sends 66 Calif. Students Home

Measles Scare Sends 66 Calif. Students Home

AP (Jan. 29, 2015) Officials say 66 students at a Southern California high school have been told to stay home through the end of next week because they may have been exposed to measles and are not vaccinated. (Jan. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins