Featured Research

from universities, journals, and other organizations

Aging: Peroxisomes have two independent proliferation mechanisms

Date:
May 30, 2011
Source:
University of Groningen
Summary:
Peroxisomes are cell organelles that can cause disease and aging processes if they do not function properly. Researchers have now demonstrated that peroxisomes can be created by two independent processes, one of which serves as a kind of ‘backup’.

Peroxisomes are cell organelles that can cause disease and aging processes if they do not function properly. For the first time ever, University of Groningen researchers have demonstrated that peroxisomes can be created by two independent processes, one of which serves as a kind of 'backup'. The study was published in the 23 May issue of the Journal of Cell Biology.

Related Articles


Peroxisomes are cell organelles that play an important role in hydrogen peroxide and fatty acid metabolism. Impaired peroxisome function can lead to serious diseases and contributes to aging processes.

Lack of clarity

Two mechanisms by which peroxisomes proliferate are known: division of an existing peroxisome and creation of a new one by budding from another cell organelle, the endoplasmic reticulum (ER). There is a lack of clarity in scientific circles regarding the status of the two mechanisms.

Independent after all

In their Journal of Cell Biology article, the Groningen researchers are the first to describe the proteins which are essential in creating peroxisomes from the ER. This discovery was subsequently used to inhibit the formation of these proteins. It transpired that when ER peroxisome production ceased, this had little or no effect on the numbers of peroxisomes present in the cell. This proved that peroxisomes are indeed independent cell organelles capable of proliferation by division, just like other important cell organelles such as mitochondria.

Backup

Formation of organelles from the ER is probably an important backup mechanism when a cell has lost all its peroxisomes. In that case, peroxisomes can be created de novo in a cell. These results are a major contribution to the debate on the importance of the ER peroxisome formation process.


Story Source:

The above story is based on materials provided by University of Groningen. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. Saraya, A. M. Krikken, M. Veenhuis, I. J. van der Klei. Peroxisome reintroduction in Hansenula polymorpha requires Pex25 and Rho1. The Journal of Cell Biology, 2011; DOI: 10.1083/jcb.201012083

Cite This Page:

University of Groningen. "Aging: Peroxisomes have two independent proliferation mechanisms." ScienceDaily. ScienceDaily, 30 May 2011. <www.sciencedaily.com/releases/2011/05/110527080153.htm>.
University of Groningen. (2011, May 30). Aging: Peroxisomes have two independent proliferation mechanisms. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2011/05/110527080153.htm
University of Groningen. "Aging: Peroxisomes have two independent proliferation mechanisms." ScienceDaily. www.sciencedaily.com/releases/2011/05/110527080153.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins